| Title: | Extracellular degradation of agonists as an adaptive mechanism |
| Author(s): | Ladds G; Hughes M; Davey J; |
| Address: | "Department of Biological Sciences, University of Warwick, Coventry, UK" |
| ISSN/ISBN: | 1084-9521 (Print) 1084-9521 (Linking) |
| Abstract: | "Many cellular responses are initiated by the binding of an extracellular ligand to receptors at the cell surface. The removal of these ligands, or agonists, would therefore be expected to contribute to the process by which cells recover from stimulation. While dilution in the extracellular medium reduces the concentration of most agonists, many cells have developed specific mechanisms for removing particular ligands. One of the more effective mechanisms is to degrade the extracellular agonist and here we review the production and action of the enzymes responsible for the degradation of a number of these agonists" |
| Keywords: | "Acetylcholinesterase/metabolism *Adaptation, Physiological Amino Acid Sequence Animals Extracellular Space/*metabolism Humans Ligands Molecular Sequence Data Peptides/metabolism Pheromones/metabolism Receptors, Cell Surface/*agonists Yeasts/metabolism/phy;" |
| Notes: | "MedlineLadds, G Hughes, M Davey, J eng Wellcome Trust/United Kingdom Research Support, Non-U.S. Gov't Review England 1998/05/26 Semin Cell Dev Biol. 1998 Apr; 9(2):111-8. doi: 10.1006/scdb.1997.0215" |
