| Title: | Beta-caryophyllene enhances wound healing through multiple routes |
| Author(s): | Koyama S; Purk A; Kaur M; Soini HA; Novotny MV; Davis K; Kao CC; Matsunami H; Mescher A; |
| Address: | "Medical Sciences, School of Medicine, Indiana University, Bloomington, IN, United States of America. School of Public Health, Indiana University, Bloomington, IN, United States of America. Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States of America. Department of Chemistry, and Institute for Pheromone Research, Indiana University, Bloomington, Indiana, United States of America. Department of Biology, Biotechnology Program, Indiana University, Bloomington, IN, United States of America. Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana, United States of America. Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, North Carolina, United States of America. Department of Anatomy and Cell Biology, School of Medicine, Indiana University, Bloomington, Indiana, United States of America" |
| DOI: | 10.1371/journal.pone.0216104 |
| ISSN/ISBN: | 1932-6203 (Electronic) 1932-6203 (Linking) |
| Abstract: | "Beta-caryophyllene is an odoriferous bicyclic sesquiterpene found in various herbs and spices. Recently, it was found that beta-caryophyllene is a ligand of the cannabinoid receptor 2 (CB2). Activation of CB2 will decrease pain, a major signal for inflammatory responses. We hypothesized that beta-caryophyllene can affect wound healing by decreasing inflammation. Here we show that cutaneous wounds of mice treated with beta-caryophyllene had enhanced re-epithelialization. The treated tissue showed increased cell proliferation and cells treated with beta-caryophyllene showed enhanced cell migration, suggesting that the higher re-epithelialization is due to enhanced cell proliferation and cell migration. The treated tissues also had up-regulated gene expression for hair follicle bulge stem cells. Olfactory receptors were not involved in the enhanced wound healing. Transient Receptor Potential channel genes were up-regulated in the injured skin exposed to beta-caryophyllene. Interestingly, there were sex differences in the impact of beta- caryophyllene as only the injured skin of female mice had enhanced re-epithelialization after exposure to beta-caryophyllene. Our study suggests that chemical compounds included in essential oils have the capability to improve wound healing, an effect generated by synergetic impacts of multiple pathways" |
| Keywords: | "Animals Cell Movement/drug effects Cell Proliferation/drug effects Female Hair Follicle/metabolism Inflammation/drug therapy Keratinocytes/metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Polycyclic Sesquiterpenes/*pharmacology Re-Epithelialization;" |
| Notes: | "MedlineKoyama, Sachiko Purk, Anna Kaur, Manpreet Soini, Helena A Novotny, Milos V Davis, Keith Kao, C Cheng Matsunami, Hiroaki Mescher, Anthony eng R01 DC014423/DC/NIDCD NIH HHS/ R01 DC016224/DC/NIDCD NIH HHS/ Research Support, Non-U.S. Gov't 2019/12/17 PLoS One. 2019 Dec 16; 14(12):e0216104. doi: 10.1371/journal.pone.0216104. eCollection 2019" |
