| Title: | Compounds for expanding the descriptor space for characterizing separation systems |
| Author(s): | Karunasekara T; Poole CF; |
| Address: | "Department of Chemistry, Wayne State University, Detroit, MI 48202, USA" |
| DOI: | 10.1016/j.chroma.2012.09.104 |
| ISSN/ISBN: | 1873-3778 (Electronic) 0021-9673 (Linking) |
| Abstract: | "A combination of gas chromatography and liquid-liquid partitions in totally organic biphasic systems is used to determine descriptor values for compounds of low volatility suitable for characterizing open tubular columns at high temperatures. The descriptor database of varied compounds includes several difficult to determine by conventional techniques due to their low water solubility or stability. The descriptor database facilitates an expansion of the descriptor space and compound variation for characterizing separation systems. As an application the descriptor database is used to determine the system constants for SPB-Octyl, HP-5, Rxi-5Sil MS, Rtx-440, and Rtx-OPP for the temperature range 200-300 degrees C. As an example of the broader affect of temperature on column selectivity the variation of the system constants for Rtx-440 over the temperature range 60-300 degrees C is described in detail. These studies demonstrate the persistence of polar interactions to the highest temperature studied and that at high temperatures selectivity differences persist for moderately polar stationary phases" |
| Keywords: | "Chemical Fractionation/*methods Chromatography, Gas/*methods Hot Temperature *Models, Chemical Organic Chemicals/chemistry/isolation & purification;" |
| Notes: | "MedlineKarunasekara, Thushara Poole, Colin F eng Netherlands 2012/10/24 J Chromatogr A. 2012 Nov 30; 1266:124-30. doi: 10.1016/j.chroma.2012.09.104. Epub 2012 Oct 3" |
