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Chem Senses

Title:		"Different profiles of main and accessory olfactory bulb mitral/tufted cell projections revealed in mice using an anterograde tracer and a whole-mount, flattened cortex preparation"
Author(s):		Kang N; Baum MJ; Cherry JA;
Address:		"Department of Biology, Boston University, Boston, MA 02215, USA"
Journal Title:		Chem Senses
Year:		2011
Volume:		20101221
Issue:		3
Page Number:		251 - 260
DOI:		10.1093/chemse/bjq120
ISSN/ISBN:		1464-3553 (Electronic) 0379-864X (Print) 0379-864X (Linking)
Abstract:		"A whole-mount, flattened cortex preparation was developed to compare profiles of axonal projections from main olfactory bulb (MOB) and accessory olfactory bulb (AOB) mitral and tufted (M/T) cells. After injections of the anterograde tracer, Phaseolus vulgaris leucoagglutinin, mapping of labeled axons using a Neurolucida system showed that M/T cells in the AOB sent axons primarily to the medial and posterior lateral cortical amygdala, with minimal branching into the piriform cortex. By contrast, M/T cells in the MOB displayed a network of collaterals that branched off the primary axon at several levels of the lateral olfactory tract (LOT). Collaterals emerging from the LOT into the anterior piriform cortex were often observed crossing into the posterior piriform cortex. M/T cells in the dorsal MOB extended fewer collaterals from the primary axon in the rostral LOT than did M/T cells from the anterior or ventral MOB. MOB M/T cells that projected to the medial amygdala did not do so exclusively, also sending collaterals to the anterior cortical amygdala as well as to olfactory cortical regions. This arrangement may be related to the ability of social experience to modify the response of mice to volatile pheromones detected by the main olfactory system"
Keywords:		Animals Axons/chemistry/metabolism Contrast Media/metabolism Fluorescent Dyes/metabolism Male Mice Olfactory Bulb/*anatomy & histology/chemistry/metabolism Olfactory Pathways/anatomy & histology/chemistry Phytohemagglutinins/metabolism;
Notes:		"MedlineKang, Ningdong Baum, Michael J Cherry, James A eng R01 DC 008962/DC/NIDCD NIH HHS/ Research Support, N.I.H., Extramural England 2010/12/24 Chem Senses. 2011 Mar; 36(3):251-60. doi: 10.1093/chemse/bjq120. Epub 2010 Dec 21"