| Title: | Advanced Diagnostic Technology of Volatile Organic Compounds Real Time analysis Analysis From Exhaled Breath of Gastric Cancer Patients Using Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry |
| Author(s): | Jung YJ; Seo HS; Kim JH; Song KY; Park CH; Lee HH; |
| Address: | "Division of Gastrointestinal Surgery, Department of Surgery, Catholic Cancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, South Korea" |
| ISSN/ISBN: | 2234-943X (Print) 2234-943X (Electronic) 2234-943X (Linking) |
| Abstract: | "BACKGROUND: Screening endoscopy is considered to be the most accurate tool for early detection of gastric cancer, but it is both invasive and costly. It is therefore essential to develop cost-effective and non-invasive diagnostic tools for gastric cancer. The aim of this study is to investigate the presence of certain volatile organic compounds (VOCs) associated with gastric cancer and to survey the usefulness of VOCs as screening tools of gastric cancer. METHODS: The present study was conducted prospectively to identify the relationship between gastric cancer and specific VOCs quantified by mass spectrometry. Exhaled breath samples from a total of 43 participants were analysed. This study was approved by the Institutional Review Board of the College of Medicine, Catholic University of Korea (KC16TISI0598), and registered to clinical research information service (KCT0004356). RESULTS: Nine VOCs differed significantly between the control and cancer patient groups. When participants were divided into control, early gastric cancer (EGC), and advanced gastric cancer (AGC) groups, seven VOCs remained significantly different. Of these, four (propanal, aceticamide, isoprene and 1,3 propanediol) showed gradual increases as cancer advanced, from normal control to EGC to AGC. In receiver operating characteristic curves for these four VOCs, the area under the curve for gastric cancer prediction was highest (0.842) when more than two VOCs were present. CONCLUSIONS: The present study offers potential directions for non-invasive gastric cancer screening, and may inspire advanced diagnostic technologies in the era of smart home healthcare. However, despite the high accuracy, cancer-specific VOCs from several studies on different populations, and analytic methods show inconsistency, it is necessary to establish standards for each analytical method, and to validate on each population" |
| Keywords: | breath analysis diagnosis screening stomach neoplasm volatile organic compound; |
| Notes: | "PubMed-not-MEDLINEJung, Yoon Ju Seo, Ho Seok Kim, Ji Hyun Song, Kyo Young Park, Cho Hyun Lee, Han Hong eng Switzerland 2021/05/18 Front Oncol. 2021 Apr 29; 11:560591. doi: 10.3389/fonc.2021.560591. eCollection 2021" |
