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Eur Respir Rev

Title:		Identifying risk factors for COPD and adult-onset asthma: an umbrella review
Author(s):		Holtjer JCS; Bloemsma LD; Beijers R; Cornelissen MEB; Hilvering B; Houweling L; Vermeulen RCH; Downward GS; Maitland-van der Zee AH; consortium PO;
Address:		"Department of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands. Department of Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands. Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands. Amsterdam Public Health, Amsterdam, The Netherlands. Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Department of Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands a.h.maitland@amsterdamumc.nl"
Journal Title:		Eur Respir Rev
Year:		2023
Volume:		20230503
Issue:		168
Page Number:		-
DOI:		10.1183/16000617.0009-2023
ISSN/ISBN:		1600-0617 (Electronic) 0905-9180 (Print) 0905-9180 (Linking)
Abstract:		"BACKGROUND: COPD and adult-onset asthma (AOA) are the most common noncommunicable respiratory diseases. To improve early identification and prevention, an overview of risk factors is needed. We therefore aimed to systematically summarise the nongenetic (exposome) risk factors for AOA and COPD. Additionally, we aimed to compare the risk factors for COPD and AOA. METHODS: In this umbrella review, we searched PubMed for articles from inception until 1 February 2023 and screened the references of relevant articles. We included systematic reviews and meta-analyses of observational epidemiological studies in humans that assessed a minimum of one lifestyle or environmental risk factor for AOA or COPD. RESULTS: In total, 75 reviews were included, of which 45 focused on risk factors for COPD, 28 on AOA and two examined both. For asthma, 43 different risk factors were identified while 45 were identified for COPD. For AOA, smoking, a high body mass index (BMI), wood dust exposure and residential chemical exposures, such as formaldehyde exposure or exposure to volatile organic compounds, were amongst the risk factors found. For COPD, smoking, ambient air pollution including nitrogen dioxide, a low BMI, indoor biomass burning, childhood asthma, occupational dust exposure and diet were amongst the risk factors found. CONCLUSIONS: Many different factors for COPD and asthma have been found, highlighting the differences and similarities. The results of this systematic review can be used to target and identify people at high risk for COPD or AOA"
Keywords:		"Adult Humans Child *Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology/etiology *Asthma/diagnosis/epidemiology Risk Factors *Air Pollution Dust Environmental Exposure/adverse effects;"
Notes:		"MedlineHoltjer, Judith C S Bloemsma, Lizan D Beijers, Rosanne J H C G Cornelissen, Merel E B Hilvering, Bart Houweling, Laura Vermeulen, Roel C H Downward, George S Maitland-Van der Zee, Anke-Hilse eng Review Systematic Review England 2023/05/04 Eur Respir Rev. 2023 May 3; 32(168):230009. doi: 10.1183/16000617.0009-2023. Print 2023 Jun 30"