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MicroPubl Biol

Title:		ODR-1 acts in AWB neurons to determine the sexual identity of C. elegans pheromone blends
Author(s):		Aprison EZ; Ruvinsky I;
Address:		"Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA"
Journal Title:		MicroPubl Biol
Year:		2022
Volume:		20220113
Issue:
Page Number:		-
DOI:		10.17912/micropub.biology.000507
ISSN/ISBN:		2578-9430 (Electronic) 2578-9430 (Linking)
Abstract:		"Valence of animal pheromone blends can vary due to differences in relative abundance of individual components. For example, in C. elegans, whether a pheromone blend is perceived as 'male' or 'hermaphrodite' is determined by the ratio of concentrations of ascr#10 and ascr#3. The neuronal mechanisms that evaluate this ratio are not currently understood. We present data that suggest that the function of guanylyl cyclase ODR-1 in AWB neurons is required for the effect of ascr#3 that counteracts the activity of ascr#10. This finding defines a new module in the neuronal mechanism that determines the sexual identity of C. elegans pheromone"
Keywords:
Notes:		"PubMed-not-MEDLINEAprison, Erin Z Ruvinsky, Ilya eng 2022/01/21 MicroPubl Biol. 2022 Jan 13; 2022:10.17912/micropub.biology.000507. doi: 10.17912/micropub.biology.000507. eCollection 2022"