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Environ Toxicol Pharmacol

Title:		Mechanism of acute inhalation toxicity of alkanes and aliphatic alcohols
Author(s):		Hau KM; Connell DW; Richardson BJ;
Address:		"Faculty of Environmental Sciences, Griffith University, Queensland, Brisbane, Australia"
Journal Title:		Environ Toxicol Pharmacol
Year:		1999
Volume:		7
Issue:		3
Page Number:		159 - 167
DOI:		10.1016/s1382-6689(99)00010-1
ISSN/ISBN:		1382-6689 (Print) 1382-6689 (Linking)
Abstract:		"This study investigated the mechanism of non-specific toxicity of non-reactive volatile organic compounds by using data reported in the literature. Inhalation toxicity data, in terms of LC(50) for alcohols and alkanes in rodents, were examined in relation to their partitioning behaviour in the biological system. Regression analysis of the data showed that, after the elimination of the kinetic influence in the absorption process, lethal toxicity increases linearly with the octanol-air partition coefficient in a homologous series. Comparing this relationship with that for anaesthesia, it could be concluded that lethal toxicity of the test chemical series probably acts on the lipid bilayer plasma membrane through a non-specific biophysical mechanism similar to anaesthesia. The critical concentration hypothesis appears to be valid for lethal toxicity of the test series. It was also shown that toxicity data for the test series by other routes, namely oral, intraperitoneal and intravenous, give a similar toxicity-partition relationship to that by inhalation"
Keywords:
Notes:		"PubMed-not-MEDLINEHau, K M Connell, D W Richardson, B J eng Netherlands 1999/07/01 Environ Toxicol Pharmacol. 1999 Jul; 7(3):159-67. doi: 10.1016/s1382-6689(99)00010-1"