| Title: | Diagnostic biomarkers for lung cancer prevention |
| Author(s): | Gasparri R; Romano R; Sedda G; Borri A; Petrella F; Galetta D; Casiraghi M; Spaggiari L; |
| Address: | "Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy. Department of Molecular Medicine, University of Pavia, Pavia, Italy Current address: Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy Department of Oncology and Emato-Oncology, University of Milan, Milan, Italy" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "Lung cancer is the leading cause of death for neoplasm. Lung cancer mortality is frequently associated with late diagnosis, therefore an early diagnosis is a key factor to significantly improve overall survival in high risk populations of asymptomatic patients. Conventional cancer screenings (low-dose computed tomography or chest x-ray) today offer early detection but are invasive and expensive. Previously these studies evaluated the solid and topographic cancer structure and morphology. Today the concept of tumor has been remodelled, being defined as a disease that has its own genetic, biological and metabolic identity; it is on this new awareness that we should base new screening methods. Recent research has shown great reliability of new tests such as exhaled breath analysis, serum biomarkers and urine analysis in early diagnosis of lung cancer. Analysis of new biomarkers associated with the high specificity of these new screening methods, which are non-invasive, safe, inexpensive and simple to perform, could allow a non-invasive approach to determine a big change in the early diagnosis of cancer and its survival rate. Furthermore, these new techniques put the patient at the core of a non-invasive diagnostic process and ensure a better quality of life during medical diagnosis. In this article, we want to analyze the possible benefits of these new and promising methods, suggesting a possible combination between them to ensure, as soon as possible, an early and effective diagnosis of lung cancer with a special focus on the patient, in a new era of personalized medicine" |
| Keywords: | "Biomarkers, Tumor/*analysis/genetics/immunology Breath Tests Exhalation Humans Lung Neoplasms/*diagnosis/immunology/*prevention & control/urine MicroRNAs/genetics/metabolism Volatile Organic Compounds/analysis;" |
| Notes: | "MedlineGasparri, Roberto Romano, Rosalia Sedda, Giulia Borri, Alessandro Petrella, Francesco Galetta, Domenico Casiraghi, Monica Spaggiari, Lorenzo eng Review England 2017/10/17 J Breath Res. 2018 Feb 6; 12(2):027111. doi: 10.1088/1752-7163/aa9386" |
