| Title: | Interference of chlorofluorocarbon (CFC)-containing inhalers with measurements of volatile compounds using selected ion flow tube mass spectrometry |
| Author(s): | Epton MJ; Ledingham K; Dummer J; Hu WP; Rhodes B; Senthilmohan ST; Scotter JM; Allardyce R; Cook J; Swanney MP; |
| Address: | "Department of Medicine, University of Otago, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand. michael.epton@chmeds.ac.nz" |
| Journal Title: | Rapid Commun Mass Spectrom |
| ISSN/ISBN: | 0951-4198 (Print) 0951-4198 (Linking) |
| Abstract: | "Selected ion flow tube mass spectrometry (SIFT-MS) is a sensitive technique capable of measuring volatile compounds (VCs) in complex gas mixtures in real time; it is now being applied to breath analysis. We investigated the effect of inhalers containing chlorofluorocarbons (CFCs) on the detection and measurement of haloamines in human breath. SIFT-MS mass scans (MS) and selected ion monitoring (SIM) scans were performed on three healthy non-smoking volunteers before and after inhalation of the following medications: Combiventtrade mark metered-dose inhaler (MDI) (CFC-containing); Ventolintrade mark MDI (CFC-free); Atroventtrade mark MDI (CFC-free), Beclazonetrade mark MDI (CFC-containing); Duolintrade mark nebuliser. In addition, the duration of the persistence of the mass/charge ratios was measured for 20 h. Inhalers containing CFCs generated large peaks at m/z 85, 87, 101, 103 and 105 in vitro and in vivo, consistent with the predicted product ions of CFCs 12, 114 and 11. No such peaks were seen with Duolintrade mark via nebuliser, or CFC-free MDIs. We conclude that measurement of VCs, such as haloamines, with product ions of similar m/z values to the ions found for CFCs would be significantly affected by the presence of CFCs in inhalers. This issue needs to be accounted for prior to the measurement of VCs in breath in people using inhalers containing CFCs" |
| Keywords: | Amines/*analysis Breath Tests Chlorofluorocarbons/*chemistry Humans Mass Spectrometry/*methods *Nebulizers and Vaporizers Volatile Organic Compounds/*analysis; |
| Notes: | "MedlineEpton, Michael J Ledingham, Katherine Dummer, Jack Hu, Wan-Ping Rhodes, Bronwen Senthilmohan, Senti T Scotter, Jennifer M Allardyce, Randall Cook, Julie Swanney, Maureen P eng Research Support, Non-U.S. Gov't England 2009/01/07 Rapid Commun Mass Spectrom. 2009 Feb; 23(3):443-7. doi: 10.1002/rcm.3875" |
