| Title: | "Gestational and lactational exposure to BPA, but not BPS, negatively impacts trabecular microarchitecture and cortical geometry in adult male offspring" |
| Author(s): | Dirkes RK; Welly RJ; Mao J; Kinkade J; Vieira-Potter VJ; Rosenfeld CS; Bruzina PS; |
| Address: | "Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, United States of America. Biomedical Sciences, Christopher S. Bond Life Sciences Center, MU Institute for Data Science and Informatics, Thompson Center for Autism and Behavioral Disorders, Genetics Area Program, University of Missouri, Columbia, MO, United States of America" |
| DOI: | 10.1016/j.bonr.2021.101147 |
| ISSN/ISBN: | 2352-1872 (Print) 2352-1872 (Electronic) 2352-1872 (Linking) |
| Abstract: | "Bisphenol-A (BPA) and bisphenol-S (BPS) are endocrine disrupting chemicals (EDCs) found primarily in plastics. Estrogen is a primary hormonal regulator of skeletal growth and development; however, the impact of gestational BPA or BPS exposure on skeletal health of offspring remains relatively unknown. Here, adult female mice were randomized into three treatment groups: 200 mug BPA/kg BW (BPA), 200 mug BPS/kg BW (BPS) or control (CON). Animals were then further randomized to exercising (EX) or sedentary (SED) groups. Treatment continued through mating, gestation, and lactation. One male offspring from each dam (n = 6-8/group) was assessed at 16 weeks of age to evaluate effects of EDC exposure on the adult skeleton. Cortical geometry of the mid-diaphysis and trabecular microarchitecture of the distal femur were assessed via micro-CT. Biomechanical strength and mineral apposition rate of the femoral diaphysis were assessed via three-point bending and dynamic histomorphometry, respectively. Two-factor ANOVA or ANCOVA were used to determine the effects of maternal EX and BPA or BPS on trabecular and cortical bone outcomes. Maternal EX led to a significant decrease in body fat percentage and bone stiffness, independent of EDC exposure. Offspring exposed to BPA had significantly lower trabecular bone volume, trabecular number, connectivity density, cortical thickness, and greater trabecular spacing compared to BPS or CON animals. In conclusion, gestational BPA, but not BPS, exposure negatively impacted trabecular microarchitecture and cortical geometry in adult male offspring. If these findings translate to humans, this could have significant public health impacts on expecting women or those seeking to become pregnant" |
| Keywords: | Biomechanical strength Bisphenols Gestation Skeletal development; |
| Notes: | "PubMed-not-MEDLINEDirkes, Rebecca K Welly, Rebecca J Mao, Jiude Kinkade, Jessica Vieira-Potter, Victoria J Rosenfeld, Cheryl S Bruzina, Pamela S eng 2021/11/26 Bone Rep. 2021 Nov 3; 15:101147. doi: 10.1016/j.bonr.2021.101147. eCollection 2021 Dec" |
