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Analyst

Title:		Development of laser ablation dielectric barrier discharge optical emission spectrometry (LA-DBD-OES) for direct determination of sulphur and chloride in the condensed phase and its application in pharmaceutical analysis
Author(s):		Ding X; Geng C; Zhai S; Cao X; Shi Z; Liu K;
Address:		"Department of Pharmaceutical Analysis, School of Pharmacy, Qingdao University, No. 1 Ningde Road, 266071, Qingdao, China. xueluding@qdu.edu.cn"
Journal Title:		Analyst
Year:		2021
Volume:		20211206
Issue:		24
Page Number:		7537 - 7544
DOI:		10.1039/d1an01563j
ISSN/ISBN:		1364-5528 (Electronic) 0003-2654 (Linking)
Abstract:		"An infrared laser (808 nm) has been coupled with dielectric barrier discharge (DBD) for optical emission spectrometric determination of S and Cl in organic compounds. The use of a continuous wave IR laser with an output power of 1-2 W allows volatilization of analytes from condensed surfaces. Analytes thermally delivered to the gas phase are excited and atomized by the DBD plasma triggered by an alternating voltage of 10 kV at 25 kHz under atmospheric pressure. Direct analysis of S- and Cl-containing organics in manufactured tablets by measuring the S and Cl emissions resulted in a dynamic range of 0.5%-20% with linearities (R(2)) above 0.93 and limits of detection (LODs) in the mug g(-1) range. The detection precision was examined by measuring inter-day and intra-day reproducibilities, leading to relative standard deviations (RSDs) ranging from 4.6% to 15.0%. The feasibility of LA-DBD-OES was further demonstrated with commercial pharmaceutical tablets of sulfadiazine (SDZ) and chloramphenicol (CAP). There is the potential for probing the tablet uniformity by monitoring the elemental emissions of S and Cl. Quantitative results of the commercial tablets were consistent with the indication amounts and were verified by HPLC measurements. All these results suggest the proposed methodology as a promising tool for online analysis of solids and pharmaceutical tablets with minimal sample treatments and rapid detection response"
Keywords:		Chlorides *Laser Therapy *Pharmaceutical Preparations Spectrum Analysis Sulfur;
Notes:		"MedlineDing, Xuelu Geng, Chaoqun Zhai, Suhan Cao, Xiaoyan Shi, Zhenyan Liu, Kun eng England 2021/11/24 Analyst. 2021 Dec 6; 146(24):7537-7544. doi: 10.1039/d1an01563j"