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« Previous Abstract"Personal exposure to 25 volatile organic compounds. EPA's 1987 team study in Los Angeles, California"    Next AbstractUptake and decay of volatile organic compounds at environmental concentrations: application of a four-compartment model to a chamber study of five human subjects »

Environ Health Perspect


Title:Recent advances in measuring exhaled breath and estimating exposure and body burden for volatile organic compounds (VOCs)
Author(s):Wallace LA; Pellizzari ED;
Address:"Atmospheric Research and Exposure Assessment Laboratory, Warrenton, VA 22091, USA"
Journal Title:Environ Health Perspect
Year:1995
Volume:103 Suppl 3
Issue:Suppl 3
Page Number:95 - 98
DOI: 10.1289/ehp.95103s395
ISSN/ISBN:0091-6765 (Print) 0091-6765 (Linking)
Abstract:"An improved portable breath measurement method has been developed that allows 1-min sampling times. The equipment has been successfully tested in field and chamber studies. Results of these studies suggest that breath levels following known exposures are predictable and reproducible across a small number of volunteers. The residence times in the body and the distribution in body compartments of several common air toxics have been determined. A simple four-compartment linear model is capable of fitting the observed data. The main parameters of the model include the fraction f of the parent compound exhaled under steady-state conditions and the residence times tau i, in the tau ith compartment. The values of these parameters for several VOCs and for the four body compartments (blood, vessel-rich tissues, vessel-poor tissues, and fat) are provided"
Keywords:Body Burden *Breath Tests *Environmental Exposure *Environmental Monitoring *Hazardous Substances Humans;
Notes:"MedlineWallace, L A Pellizzari, E D eng Review 1995/04/01 Environ Health Perspect. 1995 Apr; 103 Suppl 3(Suppl 3):95-8. doi: 10.1289/ehp.95103s395"

 
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