| Title: | Partial isolation of a pheromone accelerating puberty in female mice |
| Author(s): | Vandenbergh JG; Whitsett JM; Lombardi JR; |
| ISSN/ISBN: | 0022-4251 (Print) 0022-4251 (Linking) |
| Abstract: | "The sexual development of female mice is accelerated by exposure to an adult male or to male urine. The component of the urine responsible for this effect is androgen-dependent, heat labile, nondialysable, precipitatable with ammonium sulphate, and is not extractable in ether. These results indicate that the pheromone causing accelerated sexual development is associated with a protein component of male urine. Tests of the active fraction after digestion with proteolytic enzymes suggest that the pheromone may be a portion of a protein or a substance bound to a protein" |
| Keywords: | Adult Ammonium Sulfate Animals Biological Assay Body Weight/drug effects Chemical Precipitation Dialysis Female Hot Temperature Humans Male Mice Organ Size/drug effects Pheromones/*isolation & purification/urine Pronase/metabolism Proteinuria Puberty/*dru; |
| Notes: | "MedlineVandenbergh, J G Whitsett, J M Lombardi, J R eng Research Support, U.S. Gov't, Non-P.H.S. England 1975/06/01 J Reprod Fertil. 1975 Jun; 43(3):515-23. doi: 10.1530/jrf.0.0430515" |
