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Exp Cell Res

Title:		Structure-function relationships of pheromones of the ciliate Euplotes raikovi with mammalian growth factors: cross-reactivity between Er-1 and interleukin-2 systems
Author(s):		Vallesi A; Giuli G; Ghiara P; Scapigliati G; Luporini P;
Address:		"Dipartimento di Biologia Molecolare, Cellulare e Animale, University of Camerino, Italy"
Journal Title:		Exp Cell Res
Year:		1998
Volume:		241
Issue:		1
Page Number:		253 - 259
DOI:		10.1006/excr.1998.4056
ISSN/ISBN:		0014-4827 (Print) 0014-4827 (Linking)
Abstract:		"Diffusible protein signals of the ciliate Euplotes raikovi, denoted as pheromones, have functionally been linked with prototypic growth factors of animal cells by the demonstration that they not only induce a temporary cell union in mating pairs, by acting in a paracrine-like fashion, but can also bind to cells in autocrine fashion and promote their vegetative (mitotic) proliferation. It is now shown that pheromone Er-1 is capable of binding to the alpha and beta chains of the multimeric IL-2 receptor on mammalian cells and that IL-2 can, in turn, bind to the putative cell receptor of this pheromone. Similarities in the IL-2 and Er-1 structures support these findings and raise controversial implications with regard to their evolutionary significance"
Keywords:		Amino Acid Sequence Animals Chemoreceptor Cells/metabolism Cross Reactions Euplotes/*chemistry Growth Substances/*chemistry/metabolism Interleukin-2/chemistry/metabolism Membrane Proteins/chemistry/metabolism Pheromones/*chemistry/metabolism Protein Bindi;
Notes:		"MedlineVallesi, A Giuli, G Ghiara, P Scapigliati, G Luporini, P eng 1998/06/20 Exp Cell Res. 1998 May 25; 241(1):253-9. doi: 10.1006/excr.1998.4056"