| Title: | Tuft calcium spikes in accessory olfactory bulb mitral cells |
| Address: | "Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA. nurban@cmu.edu" |
| DOI: | 10.1523/JNEUROSCI.0297-05.2005 |
| ISSN/ISBN: | 1529-2401 (Electronic) 0270-6474 (Print) 0270-6474 (Linking) |
| Abstract: | "The mammalian accessory olfactory system is critical for the detection and identification of pheromones and the representation of complex stimuli including sex, genetic relatedness, and individual identity. Mitral cells, the principal cells of the accessory olfactory bulb (AOB), receive monosynaptic input from the sensory periphery and already show highly specific response properties, firing selectively for combinations of genetic markers and gender-specific cues. Vomeronasal sensory neuron axons form synapses onto distal tuft-like branches of mitral cell primary dendrites. We have studied dendritic excitability and synaptic integration in AOB mitral cell dendrites, and we show that dendrites of accessory olfactory bulb mitral cells support action potential propagation and can fire regenerative spike-like events that are likely to contribute to the integration of inputs to these cells. These tuft spikes may be important for the specificity of AOB mitral cell responses" |
| Keywords: | "Action Potentials/*physiology Animals Animals, Newborn Axons/physiology Calcium/*metabolism Dendrites/physiology Electric Stimulation/methods Image Processing, Computer-Assisted/methods In Vitro Techniques Mice Neurons/cytology/*physiology Olfactory Bulb/;" |
| Notes: | "MedlineUrban, Nathaniel N Castro, Jason B eng R01 DC005798/DC/NIDCD NIH HHS/ R21 DC006631/DC/NIDCD NIH HHS/ R01 DC005798-01/DC/NIDCD NIH HHS/ R21 DC006631-01/DC/NIDCD NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. 2005/05/20 J Neurosci. 2005 May 18; 25(20):5024-8. doi: 10.1523/JNEUROSCI.0297-05.2005" |
