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Chemosphere

Title:		Repeated measurements of 21 urinary metabolites of volatile organic compounds and their associations with three selected oxidative stress biomarkers in 0-7-year-old healthy children from south and central China
Author(s):		Song W; Han Q; Wan Y; Qian X; Wei M; Jiang Y; Wang Q;
Address:		"MOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: wenjs@hust.edu.cn. Institute of Environmental Health, Wuhan Centers for Disease Control & Prevention, Wuhan, Hubei, 430024, PR China. Electronic address: hanqing@whcdc.org. Institute of Environmental Health, Wuhan Centers for Disease Control & Prevention, Wuhan, Hubei, 430024, PR China. Electronic address: yanjian.wan@whcdc.org. Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: d201981370@hust.edu.cn. MOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: d201981360@hust.edu.cn. Nanshan District Centers for Disease Control and Prevention, Shenzhen, Guangdong, 518054, PR China. Electronic address: wangtiedan0111@126.com. MOE Key Lab of Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, PR China. Electronic address: wangqi_tj@hust.edu.cn"
Journal Title:		Chemosphere
Year:		2022
Volume:		20210830
Issue:		Pt 2
Page Number:		132065 -
DOI:		10.1016/j.chemosphere.2021.132065
ISSN/ISBN:		1879-1298 (Electronic) 0045-6535 (Linking)
Abstract:		"Human beings are extensively and concurrently exposed to multiple volatile organic compounds (VOCs, including some Class I human carcinogens), which may induce oxidative stress in human body. Data on urinary metabolites of VOCs (mVOCs) among young children are limited. No studies have examined their inter-day variability of mVOCs and their associations with oxidative stress biomarkers (OSBs) using repeated urine samples from children. In this study, we measured twenty one mVOCs and three OSBs [8-hydroxy-2'-deoxyguanosine (8-OHdG; for DNA), 8-hydroxyguanosine (8-OHG; for RNA], and 4-hydroxy nonenal mercapturic acid (HNEMA; for lipid)] in 390 urine samples of 130 children (three samples on three consecutive days provided by each participant) aged 0-7 years from September 2018 to January 2019 in Shenzhen, south China, and Wuhan, central China. HPMMA (3-hydroxypropyl-1-methyl mercapturic acid/N-Acetyl-S-(3-hydroxypropyl-1-methyl)-l-cysteine), 3HPMA (3-hydroxypropyl mercapturic acid/N-Acetyl-S-(3-hydroxypropyl)-l-cysteine), and ATCA (2-aminothiazoline-4-carboxylic acid) had higher specific gravity-adjusted median concentrations (1 383, 286, and 273 mug/L, respectively) than the others. Intraclass correlation coefficients of mVOCs ranged from 0.29 to 0.71. After false-discovery rate (FDR, defined as FDR q-value < 0.05) adjustment, linear mixed-effects models revealed that 14 mVOCs were positively associated with 8-OHdG (beta range: 0.09-0.37), 11 mVOCs were positively associated with 8-OHG (beta range: 0.08-0.30), and 11 mVOCs were positively associated with HNEMA (beta range: 0.21-0.70) in urine. Considering the weight of the mVOC index accounted for the associations, based on the weighted quantile sum regression model, parent compounds of DHBMA (3,4-dihydroxybutyl mercapturic acid/N-Acetyl-S-(3,4-dihydroxybutyl)-l-cysteine) and t,t-MA (trans,trans-muconic acid) should be listed as priority VOCs for management to mitigate health risks. For the first time, this study characterized the inter-day variability of urinary mVOCs and their associations with selected OSBs (8-OHdG, 8-OHG, and NHEMA) in young, healthy Chinese children"
Keywords:		"8-Hydroxy-2'-Deoxyguanosine Biomarkers Child Child, Preschool China Humans Infant Infant, Newborn Oxidative Stress *Volatile Organic Compounds Co-exposure Human biomonitoring Inter-day variability Oxidative stress biomarkers Uplc-ms/ms Volatile organic co;"
Notes:		"MedlineSong, Wenjing Han, Qing Wan, Yanjian Qian, Xi Wei, Muhong Jiang, Ying Wang, Qi eng England 2021/09/09 Chemosphere. 2022 Jan; 287(Pt 2):132065. doi: 10.1016/j.chemosphere.2021.132065. Epub 2021 Aug 30"