Title: | Olfactory receptor database: a sensory chemoreceptor resource |
Author(s): | Skoufos E; Marenco L; Nadkarni PM; Miller PL; Shepherd GM; |
Address: | "Center for Medical Informatics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06511, USA. emmanouil.skoufos@yale.edu" |
ISSN/ISBN: | 0305-1048 (Print) 1362-4962 (Electronic) 0305-1048 (Linking) |
Abstract: | "The Olfactory Receptor Database (ORDB) is a WWW-accessible database that has been expanded from an olfactory receptor resource to a chemoreceptor resource. It stores data on six classes of G-protein-coupled sensory chemoreceptors: (i) olfactory receptor-like proteins, (ii) vomeronasal receptors, (iii) insect olfactory receptors, (iv) worm chemo-receptors, (v) taste papilla receptors and (vi) fungal pheromone receptors. A complementary database of the ligands of these receptors (OdorDB) has been constructed and is publicly available in a pilot mode. The database schema of ORDB has been changed from traditional relational to EAV/CR (Entity-Attribute-Value with Classes and Relationships), which allows the interoperability of ORDB with other related databases as well as the creation of intra-database associations among objects. This inter-operability facilitates users to follow information from odor molecule binding to its putative receptor, to the properties of the neuron expressing the receptor, to a computational model of activity of olfactory bulb neurons. In addition, tools and resources have been added allowing users to access interactive phylogenetic trees and alignments of sensory chemoreceptors. ORDB is available via the WWW at http://ycmi.med. yale.edu/senselab/ordb/" |
Keywords: | "Base Sequence Chemoreceptor Cells/*chemistry *Databases, Factual Molecular Sequence Data Olfactory Mucosa/*chemistry User-Computer Interface;" |
Notes: | "MedlineSkoufos, E Marenco, L Nadkarni, P M Miller, P L Shepherd, G M eng T15 LM007056/LM/NLM NIH HHS/ G08 LM05583/LM/NLM NIH HHS/ R01 DC02307/DC/NIDCD NIH HHS/ T15 LM07056/LM/NLM NIH HHS/ Research Support, U.S. Gov't, P.H.S. England 1999/12/11 Nucleic Acids Res. 2000 Jan 1; 28(1):341-3. doi: 10.1093/nar/28.1.341" |