« Previous AbstractRAD9-dependent G1 arrest defines a second checkpoint for damaged DNA in the cell cycle of Saccharomyces cerevisiae    Next AbstractUse of physiological knowledge to control the invasive sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes »

J Bacteriol

Title:		"The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment"
Author(s):		Siede W; Allen JB; Elledge SJ; Friedberg EC;
Address:		"Division of Cancer Biology, Department of Radiation Oncology and Winship Cancer Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA"
Journal Title:		J Bacteriol
Year:		1996
Volume:		178
Issue:		19
Page Number:		5841 - 5843
DOI:		10.1128/jb.178.19.5841-5843.1996
ISSN/ISBN:		0021-9193 (Print) 1098-5530 (Electronic) 0021-9193 (Linking)
Abstract:		"The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S-phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle"
Keywords:		"Ataxia Telangiectasia/genetics Ataxia Telangiectasia Mutated Proteins Cell Cycle/*genetics Cell Cycle Proteins DNA-Binding Proteins Dose-Response Relationship, Radiation Fungal Proteins/*metabolism *Genes, Fungal Humans Intracellular Signaling Peptides an;"
Notes:		"MedlineSiede, W Allen, J B Elledge, S J Friedberg, E C eng CA12428/CA/NCI NIH HHS/ GM44644/GM/NIGMS NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1996/10/01 J Bacteriol. 1996 Oct; 178(19):5841-3. doi: 10.1128/jb.178.19.5841-5843.1996"