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Lung Cancer

Title:		Searching for selected VOCs in human breath samples as potential markers of lung cancer
Author(s):		Rudnicka J; Kowalkowski T; Buszewski B;
Address:		"Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87-100, Torun, Poland; Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 4 Wilenska St, 87-100 Torun, Poland. Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, 7 Gagarin St, 87-100, Torun, Poland; Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, 4 Wilenska St, 87-100 Torun, Poland. Electronic address: bbusz@chem.umk.pl"
Journal Title:		Lung Cancer
Year:		2019
Volume:		20190215
Issue:
Page Number:		123 - 129
DOI:		10.1016/j.lungcan.2019.02.012
ISSN/ISBN:		1872-8332 (Electronic) 0169-5002 (Linking)
Abstract:		"OBJECTIVE: Evaluation of the potential of combined multivariate chemometric methods for seeking markers of lung cancer. METHODS: Statistical methods such as Mann-Whitney U test, discriminant function analysis (DFA), factor analysis (FA) and artificial neural network (ANN) were applied to evaluate the obtained data from GC/MS analysis of exhaled breath. RESULTS: The total number of compounds identified by GC/MS in human breath was equal to 88. The statistical analysis indicates seven analytes which have the highest discriminatory power. Cross validation of the obtained model shows that the sensitivity was 80% and the specificity was 91.23%, while for the test group the sensitivity and specificity were both 86.36%. CONCLUSION: The application of combined statistical methods allowed to reduce the number of compounds to significant ones and indicates them as markers of lung cancer"
Keywords:		"Adult Aged Aged, 80 and over *Biomarkers, Tumor Breath Tests Discriminant Analysis *Exhalation Female Gas Chromatography-Mass Spectrometry Humans Lung Neoplasms/*diagnosis/*metabolism Male Middle Aged Neural Networks, Computer ROC Curve Volatile Organic C;"
Notes:		"MedlineRudnicka, Joanna Kowalkowski, Tomasz Buszewski, Boguslaw eng Ireland 2019/08/27 Lung Cancer. 2019 Sep; 135:123-129. doi: 10.1016/j.lungcan.2019.02.012. Epub 2019 Feb 15"