« Previous AbstractReducing chemical exposures in nail salons through owner and worker trainings: an exploratory intervention study    Next AbstractRole of pathogen-induced volatiles in the Nicotiana tabacum-Golovinomyces cichoracearum interaction »

Mol Microbiol

Title:		A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis
Author(s):		Quadbeck-Seeger C; Wanner G; Huber S; Kahmann R; Kamper J;
Address:		"Institut fur Genetik und Mikrobiologie, Ludwig-Maximilians-Universitat Munchen, Maria-Ward-Strasse 1a, D-80638 Munchen, Germany"
Journal Title:		Mol Microbiol
Year:		2000
Volume:		38
Issue:		1
Page Number:		154 - 166
DOI:		10.1046/j.1365-2958.2000.02128.x
ISSN/ISBN:		0950-382X (Print) 0950-382X (Linking)
Abstract:		"Pathogenic development in the corn smut fungus Ustilago maydis is controlled by a heterodimer of the two homeodomain proteins bE and bW which are encoded by the b mating type locus. The bE/bW heterodimer is thought to achieve its function as a transcriptional regulator of pathogenicity genes, either directly by binding to cis regulatory sequences or indirectly via a b-dependent regulatory cascade. In a screen for components of the b-dependent regulatory cascade we have isolated Rum1 (regulator U. maydis 1), a protein with similarities to the human retinoblastoma binding protein 2. Deletion of rum1 results in expression of several b regulated genes independently from their activation via the bE/bW heterodimer. rum1 mutant strains remain pathogenic, proliferate in planta, but fail to produce spores. The defect leads to an arrest in spore development at a defined stage before the spore wall is generated. Deduced from the highly conserved domain structure of Rum1 that includes a DNA-binding motif and a region known to facilitate the interaction with histone deacetylases, we propose that Rum1 functions as a transcriptional repressor through the modulation of chromatin structure"
Keywords:		"Amino Acid Sequence Base Sequence DNA Primers Fungal Proteins/chemistry/genetics/*metabolism Gene Expression Regulation, Fungal/*genetics Humans Mating Factor Molecular Sequence Data Peptides/*genetics Phenotype Repressor Proteins/chemistry/genetics/*meta;"
Notes:		"MedlineQuadbeck-Seeger, C Wanner, G Huber, S Kahmann, R Kamper, J eng Research Support, Non-U.S. Gov't England 2000/10/13 Mol Microbiol. 2000 Oct; 38(1):154-66. doi: 10.1046/j.1365-2958.2000.02128.x"