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J Antimicrob Chemother

Title:		Pheromone responses and high-level aminoglycoside resistance of conjugative plasmids of Enterococcus faecalis from Greece
Author(s):		Pournaras S; Tsakris A; Palepou MF; Papa A; Douboyas J; Antoniadis A; Woodford N;
Address:		"Department of Microbiology, AHEPA University Hospital, 54 636 Thessaloniki, Greece"
Journal Title:		J Antimicrob Chemother
Year:		2000
Volume:		46
Issue:		6
Page Number:		1013 - 1016
DOI:		10.1093/jac/46.6.1013
ISSN/ISBN:		0305-7453 (Print) 0305-7453 (Linking)
Abstract:		"Fifteen of 22 clinical isolates of Enterococcus faecalis with high-level aminoglycoside resistance isolated in Greece, which were tested for mating ability, co-transferred pheromone response genes together with aminoglycoside resistance determinants to a sensitive recipient strain. Nine of them belonged to the same pulsotype, while the remaining six isolates were genetically unrelated. The prgB gene, which encodes aggregation substance, was detected in all the clinical isolates and transconjugants by both PCR and DNA hybridization but prgA, which encodes the surface exclusion protein, was only detected in two isolates, whereas it is present in most pheromone response plasmids from other sources"
Keywords:		"Aminoglycosides Anti-Bacterial Agents/*pharmacology *Conjugation, Genetic Drug Resistance, Microbial Enterococcus faecalis/drug effects/*genetics Pheromones/*pharmacology *Plasmids;"
Notes:		"MedlinePournaras, S Tsakris, A Palepou, M F Papa, A Douboyas, J Antoniadis, A Woodford, N eng England 2000/12/05 J Antimicrob Chemother. 2000 Dec; 46(6):1013-6. doi: 10.1093/jac/46.6.1013"