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Nature

Title:		A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe
Author(s):		McLeod M; Beach D;
Address:		"Cold Spring Harbor Laboratory, New York 11724"
Journal Title:		Nature
Year:		1988
Volume:		332
Issue:		6164
Page Number:		509 - 514
DOI:		10.1038/332509a0
ISSN/ISBN:		0028-0836 (Print) 0028-0836 (Linking)
Abstract:		"In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation"
Keywords:		"Fungal Proteins/*antagonists & inhibitors/genetics/*physiology Genes, Fungal Genes, Mating Type, Fungal Mating Factor *Meiosis Peptides/physiology Phosphorylation *Protein Kinase Inhibitors Protein Kinases/genetics/physiology Recombinant Fusion Proteins/m;"
Notes:		"MedlineMcLeod, M Beach, D eng Research Support, U.S. Gov't, P.H.S. England 1988/04/07 Nature. 1988 Apr 7; 332(6164):509-14. doi: 10.1038/332509a0"