| Title: | Role of Insect and Mammal Glutathione Transferases in Chemoperception |
| Author(s): | Schwartz M; Boichot V; Fraichard S; Muradova M; Senet P; Nicolai A; Lirussi F; Bas M; Canon F; Heydel JM; Neiers F; |
| Address: | "Laboratory: Flavour Perception: Molecular Mechanims (Flavours), INRAE, CNRS, Institut Agro, Universite de Bourgogne Franche-Comte, 21000 Dijon, France. Laboratoire Interdisciplinaire Carnot de Bourgogne, UMR 6303 CNRS, Universite de Bourgogne Franche-Comte, 21078 Dijon, France. UMR 1231, Lipides Nutrition Cancer, INSERM, 21000 Dijon, France. UFR des Sciences de Sante, Universite de Bourgogne Franche-Comte, 25000 Besancon, France. Plateforme PACE, Laboratoire de Pharmacologie-Toxicologie, Centre Hospitalo-Universitaire Besancon, 25000 Besancon, France" |
| ISSN/ISBN: | 2218-273X (Electronic) 2218-273X (Linking) |
| Abstract: | "Glutathione transferases (GSTs) are ubiquitous key enzymes with different activities as transferases or isomerases. As key detoxifying enzymes, GSTs are expressed in the chemosensory organs. They fulfill an essential protective role because the chemosensory organs are located in the main entry paths of exogenous compounds within the body. In addition to this protective function, they modulate the perception process by metabolizing exogenous molecules, including tastants and odorants. Chemosensory detection involves the interaction of chemosensory molecules with receptors. GST contributes to signal termination by metabolizing these molecules. By reducing the concentration of chemosensory molecules before receptor binding, GST modulates receptor activation and, therefore, the perception of these molecules. The balance of chemoperception by GSTs has been shown in insects as well as in mammals, although their chemosensory systems are not evolutionarily connected. This review will provide knowledge supporting the involvement of GSTs in chemoperception, describing their localization in these systems as well as their enzymatic capacity toward odorants, sapid molecules, and pheromones in insects and mammals. Their different roles in chemosensory organs will be discussed in light of the evolutionary advantage of the coupling of the detoxification system and chemosensory system through GSTs" |
| Keywords: | Animals *Glutathione Transferase/metabolism *Mammals/metabolism Protein Binding Insecta/metabolism Glutathione/metabolism chemosensory organs detoxification evolution flavor glutathione transferase insects olfaction taste; |
| Notes: | "MedlineSchwartz, Mathieu Boichot, Valentin Fraichard, Stephane Muradova, Mariam Senet, Patrick Nicolai, Adrien Lirussi, Frederic Bas, Mathilde Canon, Francis Heydel, Jean-Marie Neiers, Fabrice eng ANR-16-CE21-0004-01/Agence Nationale de la Recherche/ ANR-18-CE92-0018-01/Agence Nationale de la Recherche/ ANR-22-CE21-0001/Agence Nationale de la Recherche/ ANR-20-CE21-0002/Agence Nationale de la Recherche/ Research Support, Non-U.S. Gov't Review Switzerland 2023/02/26 Biomolecules. 2023 Feb 8; 13(2):322. doi: 10.3390/biom13020322" |
