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J Occup Environ Med

Title:		Volatile Organic Compounds in Blood as Biomarkers of Exposure to JP-8 Jet Fuel Among US Air Force Personnel
Author(s):		Maule AL; Proctor SP; Blount BC; Chambers DM; McClean MD;
Address:		"Department of Environmental Health (Ms Maule, Dr Proctor, Dr McClean), Boston University School of Public Health; Division of Military Performance (Ms Maule, Dr Proctor), United States Army Research Institute of Environmental Medicine, Natick; Veterans Affairs Boston Healthcare System (Dr Proctor), Massachusetts; National Center for Environmental Health (Dr Blount, Dr Chambers), Centers for Disease Control and Prevention, Atlanta, Georgia"
Journal Title:		J Occup Environ Med
Year:		2016
Volume:		58
Issue:		1
Page Number:		24 - 29
DOI:		10.1097/JOM.0000000000000611
ISSN/ISBN:		1536-5948 (Electronic) 1076-2752 (Print) 1076-2752 (Linking)
Abstract:		"OBJECTIVE: This study aimed to evaluate blood volatile organic compound (VOC) levels as biomarkers of occupational jet propulsion fuel 8 (JP-8) exposure while controlling for smoking. METHODS: Among 69 Air Force personnel, post-shift blood samples were analyzed for components of JP-8, including ethylbenzene, toluene, o-xylene, and m/p-xylene, and for the smoking biomarker, 2,5-dimethylfuran. JP-8 exposure was characterized based on self-report and measured work shift levels of total hydrocarbons in personal air. Multivariate regression was used to evaluate the relationship between JP-8 exposure and post-shift blood VOCs while controlling for potential confounding from smoking. RESULTS: Blood VOC concentrations were higher among US Air Force personnel who reported JP-8 exposure and work shift smoking. Breathing zone total hydrocarbons was a significant predictor of VOC blood levels, after controlling for smoking. CONCLUSIONS: These findings support the use of blood VOCs as a biomarker of occupational JP-8 exposure"
Keywords:		"Adolescent Adult Aerospace Medicine Air Pollutants, Occupational/*analysis Benzene Derivatives/blood Biomarkers/blood Female Humans Hydrocarbons/*chemistry Male *Military Personnel Occupational Exposure/*analysis Toluene/blood Volatile Organic Compounds/*;"
Notes:		"MedlineMaule, Alexis L Proctor, Susan P Blount, Benjamin C Chambers, David M McClean, Michael D eng CC999999/ImCDC/Intramural CDC HHS/ Research Support, U.S. Gov't, Non-P.H.S. 2015/12/31 J Occup Environ Med. 2016 Jan; 58(1):24-9. doi: 10.1097/JOM.0000000000000611"