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Insect Biochem Mol Biol

Title:		Retinoid X receptor modulates olfactory attraction through Galpha signaling in the migratory locusts
Author(s):		Ma Z; Liu J;
Address:		"Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: mazy@biols.ac.cn. Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, 100101, China"
Journal Title:		Insect Biochem Mol Biol
Year:		2020
Volume:		20191106
Issue:
Page Number:		103265 -
DOI:		10.1016/j.ibmb.2019.103265
ISSN/ISBN:		1879-0240 (Electronic) 0965-1748 (Linking)
Abstract:		"Animals communicate with each other in aggregating for survival and adaptation. Solitary locusts show an olfactory transition from repulsion to attraction in aggregation. However, the molecular mechanism underlying this transition is less well known. In this study, we explored differentially expressed transcripts (DETs) during locust aggregation and identified that a functional class of general metabolism encompassed the largest number of DETs among all analyzed gene classes. Within this functional class of general metabolism, oxidoreductase mediates synthesis of retinoic acid (RA) from vitamin A and other metabolites derived from carbohydrates. The expression levels of retinaldehyde hydroxylase 1 (raldh1) and retinoid X receptor (rxr), which are two crucial genes for RA synthesis and signaling, were upregulated during 4?ª+h of crowding. Knockdown of raldh1 and rxr by RNA interference (RNAi) in the brains resulted in the loss of olfactory attraction. Moreover, inhibition of RXR by RNAi resulted in downregulated expression of Gna14, a member of the Galpha subfamily that transduces signals in G protein-coupled receptor (GPCR) pathways. Abrogating RXR signaling and Gna14 by RNAi knockdown inhibited the function of dopamine receptor 1 (DopR1) and octopamine receptor alpha1 (OctalphaR1) in modulating olfactory attraction. RXR signaling is essential for DopR1 and OctalphaR1 to mediate olfactory attraction. This study showed that RXR signaling mediates attraction by Galpha signaling and confirmed a novel link between nuclear receptor RXR and the membrane receptor GPCRs in modulating olfactory attraction"
Keywords:		"Animals Behavior, Animal/physiology Locusta migratoria/genetics/*metabolism *Pheromones RNA Interference Receptors, Biogenic Amine/metabolism Receptors, Cytoplasmic and Nuclear/metabolism Receptors, Dopamine/metabolism Retinoid X Receptors/genetics/*metab;"
Notes:		"MedlineMa, Zongyuan Liu, Jipeng eng Research Support, Non-U.S. Gov't England 2019/11/11 Insect Biochem Mol Biol. 2020 Jan; 116:103265. doi: 10.1016/j.ibmb.2019.103265. Epub 2019 Nov 6"