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Molecules

Title:		"A Study of the Chemical Composition, Antioxidant Potential, and Acute Toxicity of Bulgarian Tanacetum vulgare L. Essential Oil"
Author(s):		Karcheva-Bahchevanska D; Benbassat N; Georgieva Y; Lechkova B; Ivanova S; Ivanov K; Todorova V; Peychev L; Peychev Z; Denev P;
Address:		"Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Department of Medical Informatics, Biostatistics and E-Learning, Faculty of Public Health, Medical University-Plovdiv, 4002 Plovdiv, Bulgaria. Laboratory of Biologically Active Substances, Institute of Organic Chemistry with Centre of Phytochemistry-Bulgarian Academy of Sciences, 4000 Plovdiv, Bulgaria"
Journal Title:		Molecules
Year:		2023
Volume:		20230821
Issue:		16
Page Number:		-
DOI:		10.3390/molecules28166155
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"Common tansy (Tanacetum vulgare L.) is a plant with medicinal properties that has traditionally been used in folk medicine for its anthelmintic, antispasmodic, and choleretic effects, for the treatment of diarrhea and digestive problems, and externally, as an insecticide in veterinary practices. In the current study, we investigated, for the first time, the chemical profile and antioxidant activity of essential oil from a wild population of T. vulgare L. growing in Bulgaria. Common tansy essential oil (EO), which is rich in bicyclic monoterpenes, was obtained using hydrodistillation and characterized by using gas chromatography-mass spectrometry (GC-MS). Thirty-seven compounds were identified in Bulgarian tansy EO. Among the major constituents were oxygenated monoterpenes, including compounds such as camphor (25.24%), trans-chrysantenyl acetate (18.35%), cis-verbenol (10.58%), thujone (6.06%), eucaliptol (5.99%), and alpha-campholenal (5.98%). The analysis results identified the essential oil from T. vulgare L. grown in the western Rhodope Mountains of Bulgaria as the camphor chemotype. Furthermore, its antioxidant activity was analyzed using the oxygen radical absorbance capacity (ORAC) method and was found to be 605.4 +/- 49.3 micromol TE/mL. The essential oil was also tested for single-dose acute toxicity on Wistar rats and was found to be non-toxic by oral administration. The mean lethal dose by intraperitoneal administration was LD(50) i.p. = 14.9 g/kg body weight. The results of the conducted study can serve as a basis for the evaluation and subsequent exploration of other pharmacotherapeutic effects of the essential oil obtained from the inflorescences of the Bulgarian species T. vulgare L"
Keywords:		"Rats Animals Rats, Wistar *Oils, Volatile/pharmacology Antioxidants/pharmacology Camphor Bulgaria Plant Oils Gc/ms Tanacetum vulgare L.antioxidant activity essential oil composition in vivo acute toxicity;"
Notes:		"MedlineKarcheva-Bahchevanska, Diana Benbassat, Niko Georgieva, Yoana Lechkova, Borislava Ivanova, Stanislava Ivanov, Kalin Todorova, Velislava Peychev, Lyudmil Peychev, Zhivko Denev, Petko eng Switzerland 2023/08/26 Molecules. 2023 Aug 21; 28(16):6155. doi: 10.3390/molecules28166155"