| Title: | The repertoire of G-protein-coupled receptors in Xenopus tropicalis |
| Address: | "Shanghai Institute of Brain Functional Genomics, East China Normal University, 3663 Zhongshan Road N,, Shanghai, 200062, PR China. yolanda_jee@yahoo.com.cn" |
| ISSN/ISBN: | 1471-2164 (Electronic) 1471-2164 (Linking) |
| Abstract: | "BACKGROUND: The G-protein-coupled receptor (GPCR) superfamily represents the largest protein family in the human genome. These proteins have a variety of physiological functions that give them well recognized roles in clinical medicine. In Xenopus tropicalis, a widely used animal model for physiology research, the repertoire of GPCRs may help link the GPCR evolutionary history in vertebrates from teleost fish to mammals. RESULTS: We have identified 1452 GPCRs in the X. tropicalis genome. Phylogenetic analyses classified these receptors into the following seven families: Glutamate, Rhodopsin, Adhesion, Frizzled, Secretin, Taste 2 and Vomeronasal 1. Nearly 70% of X. tropicalis GPCRs are represented by the following three types of receptors thought to receive chemosensory information from the outside world: olfactory, vomeronasal 1 and vomeronasal 2 receptors. CONCLUSION: X. tropicalis shares a more similar repertoire of GPCRs with mammals than it does with fish. An examination of the three major groups of receptors related to olfactory/pheromone detection shows that in X. tropicalis, these groups have undergone lineage specific expansion. A comparison of GPCRs in X. tropicalis, teleost fish and mammals reveals the GPCR evolutionary history in vertebrates" |
| Keywords: | "Animals Evolution, Molecular Genome *Phylogeny Receptors, G-Protein-Coupled/*genetics Sequence Analysis, DNA Xenopus/*genetics Xenopus Proteins/*genetics;" |
| Notes: | "MedlineJi, Yanping Zhang, Zhen Hu, Yinghe eng Research Support, Non-U.S. Gov't England 2009/06/11 BMC Genomics. 2009 Jun 9; 10:263. doi: 10.1186/1471-2164-10-263" |
