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Biochem J

Title:		"Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors"
Author(s):		Hermans E; Challiss RA;
Address:		"Laboratoire de Pharmacologie, Universite Catholique de Louvain (54.10), B-1200 Brussels, Belgium. emmanuel.hermans@farl.ucl.ac.be"
Journal Title:		Biochem J
Year:		2001
Volume:		359
Issue:		Pt 3
Page Number:		465 - 484
DOI:		10.1042/0264-6021:3590465
ISSN/ISBN:		0264-6021 (Print) 1470-8728 (Electronic) 0264-6021 (Linking)
Abstract:		"In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven-transmembrane topology of the GPCR superfamily, bore little resemblance to the growing number of other cloned GPCRs. Subsequent studies have shown that there are eight mammalian mGlu receptors that, together with the calcium-sensing receptor, the GABA(B) receptor (where GABA is gamma-aminobutyric acid) and a subset of pheromone, olfactory and taste receptors, make up GPCR family C. Currently available data suggest that family C GPCRs share a number of structural, biochemical and regulatory characteristics, which differ markedly from those of the other GPCR families, most notably the rhodopsin/family A GPCRs that have been most widely studied to date. This review will focus on the group I mGlu receptors (mGlu1 and mGlu5). This subgroup of receptors is widely and differentially expressed in neuronal and glial cells within the brain, and receptor activation has been implicated in the control of an array of key signalling events, including roles in the adaptative changes needed for long-term depression or potentiation of neuronal synaptic connectivity. In addition to playing critical physiological roles within the brain, the mGlu receptors are also currently the focus of considerable attention because of their potential as drug targets for the treatment of a variety of neurological and psychiatric disorders"
Keywords:		"Animals Cations, Divalent/metabolism GTP-Binding Proteins/metabolism Humans Ligands Models, Biological Models, Molecular Neuroglia/metabolism Neurons/metabolism Phosphorylation Protein Isoforms Protein Structure, Secondary Receptor, Metabotropic Glutamate;"
Notes:		"MedlineHermans, E Challiss, R A eng Research Support, Non-U.S. Gov't Review England 2001/10/24 Biochem J. 2001 Nov 1; 359(Pt 3):465-84. doi: 10.1042/0264-6021:3590465"