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Lung Cancer

Title:		Trained dogs can identify malignant solitary pulmonary nodules in exhaled gas
Author(s):		Guirao A; Molins L; Ramon I; Sunyer G; Vinolas N; Marrades R; Sanchez D; Fibla JJ; Boada M; Hernandez J; Guzman R; Libreros A; Gomez-Caro A; Guerrero C; Agusti A;
Address:		"Institut Respiratori, Hospital Clinic, Universitat de Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address: GUIRAO@clinic.cat. Institut Respiratori, Hospital Clinic, Universitat de Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER Enfermedades Respiratorias (CIBERES), Spain. ARGUS Detection Dogs, Barcelona, Spain. CIBER Enfermedades Respiratorias (CIBERES), Spain. Institut Clinic de Malalties Hematologiques i Oncologiques, Hospital Clinic, Universitat de Barcelona, Spain. Institut Respiratori, Hospital Clinic, Universitat de Barcelona, Spain. Hospital Universitari Sagrat Cor, Barcelona, Spain"
Journal Title:		Lung Cancer
Year:		2019
Volume:		20190615
Issue:
Page Number:		230 - 233
DOI:		10.1016/j.lungcan.2019.06.008
ISSN/ISBN:		1872-8332 (Electronic) 0169-5002 (Linking)
Abstract:		"OBJECTIVES: To investigate the capacity of a trained dog to identify LC in patients with malignant SPN. METHODS: We collected 90 exhaled gas samples from 30 patients with SPN (3 samples/patient). As controls we used 61 healthy volunteers and 18 COPD patients without SNP or LC, in each of whom we collected 5 exhaled gas samples (n?ª+=?ª+395). The dog (Blat, a 4-year-old crossbreed between a Labrador Retriever and a Pitbull) and the methodology used were the same as previously reported by our group (see: https://drive.google.com/open?id=1R4mOtOtuZkTeb5iOEEv0K9r2kHKlPhWd). RESULTS: Of 30 patients with SPN, Blat recognized 27 of them as positive for LC and 3 as negative for LC. These results fully matched post-surgical pathological results. Sensibility was 0.97, Specificity 0.99, Positive Predictive value 0.97 and negative predictive value 0.99. The AUC of the ROC curve was 0.985. CONCLUSIONS: Trained dogs can identify accurately the malignant origin of SPN. It is now time to develop technology that can match canine olfaction and facilitate the implementation of this diagnostic approach in the clinic"
Keywords:		"Aged Animals Case-Control Studies Diagnosis, Differential Disease Models, Animal Dogs Female Humans Lung Neoplasms/*diagnosis/pathology Male Middle Aged Neoplasm Grading/methods ROC Curve Reproducibility of Results Solitary Pulmonary Nodule/*diagnosis/pat;"
Notes:		"MedlineGuirao, A Molins, L Ramon, I Sunyer, G Vinolas, N Marrades, R Sanchez, D Fibla, J J Boada, M Hernandez, J Guzman, R Libreros, A Gomez-Caro, A Guerrero, C Agusti, A eng Research Support, Non-U.S. Gov't Ireland 2019/06/27 Lung Cancer. 2019 Sep; 135:230-233. doi: 10.1016/j.lungcan.2019.06.008. Epub 2019 Jun 15"