| Title: | Self-Assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel |
| Author(s): | Gelain F; Luo Z; Zhang S; |
| Address: | "Institute for Stem-cell Biology, Regenerative Medicine and Innovative Therapies, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013, Italy. Center for Nanomedicine and Tissue Engineering, ASST Grande Ospedale Metropolitano Niguarda, Piazza dell'Ospedale Maggiore, 3, Milan 20162, Italy. College of Basic Medical Sciences, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China. Laboratory of Molecular Architecture, Media Lab, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139-4307, United States" |
| DOI: | 10.1021/acs.chemrev.0c00690 |
| ISSN/ISBN: | 1520-6890 (Electronic) 0009-2665 (Linking) |
| Abstract: | "Short peptides are ubiquitous in nature. They are found as hormones, pheromones, antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But no one seriously considered that peptides could be useful as scaffold hydrogel materials. There has been a significant change since 1990 after the discovery of an ionic self-complementary peptide as a very interesting repeating segment in a yeast protein. It is now recognized that self-assembling peptides made from 20 natural amino acids have real material properties. Currently, many diverse applications have been developed from these simple and designer self-assembling peptide scaffold hydrogels and are commercially available. Examples include: (1) real 3D tissue cell cultures of diverse tissue cells and various stem cells, (2) reparative and regenerative medicine as well as tissue engineering, (3) 3D tissue printing, (4) sustained releases of small molecules, growth factors, and monoclonal antibodies, and (5) accelerated wound healings of skin and diabetic ulcers as well as instant hemostatic applications in surgery. Self-assembling peptide nanobiotechnology will likely continue to expand in many directions in the coming years" |
| Keywords: | "Animals Biomechanical Phenomena Biomimetic Materials/chemistry Humans Hydrogels/*chemistry Nanofibers/chemistry Oligopeptides/*chemistry Printing, Three-Dimensional Tissue Engineering;" |
| Notes: | "MedlineGelain, Febrizio Luo, Zhongli Zhang, Shuguang eng Research Support, Non-U.S. Gov't Review 2020/11/21 Chem Rev. 2020 Dec 23; 120(24):13434-13460. doi: 10.1021/acs.chemrev.0c00690. Epub 2020 Nov 20" |
