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« Previous AbstractThe yeast G-protein homolog is involved in the mating pheromone signal transduction system    Next AbstractSpecific Substances Contained in the Exhaled Breath of Patients with Esophageal Cancer »

J Cell Sci


Title:"Yeast homolog of mammalian mitogen-activated protein kinase, FUS3/DAC2 kinase, is required both for cell fusion and for G1 arrest of the cell cycle and morphological changes by the cdc37 mutation"
Author(s):Fujimura HA;
Address:"Laboratory of Genetics and Microbiology, Developmental and Reproductive Biology Center, Yamagata, Japan"
Journal Title:J Cell Sci
Year:1994
Volume:107 ( Pt 9)
Issue:
Page Number:2617 - 2622
DOI: 10.1242/jcs.107.9.2617
ISSN/ISBN:0021-9533 (Print) 0021-9533 (Linking)
Abstract:"Saccharomyces cerevisiae FUS3/DAC2 protein kinase, a homolog of mammalian mitogen-activated protein (MAP) kinase, inactivates a G1 cyclin encoded by the CLN3 gene to arrest cell division in the G1 phase and activates a transcriptional factor STE12 in response to mating pheromone during sexual conjugation. To elucidate the role of the FUS3/DAC2 gene product in the mating process, I constructed and characterized dac2 cln3 double mutants. Here, I show that FUS3/DAC2 is required for completion of cell fusion even in the dac2 cln3 double mutants in which the pheromone response is restored, suggesting that FUS3/DAC2 plays a positive role in cell fusion during conjugation. In addition, the cdc dac2 and cdc37 ste double mutants were constructed and investigated for their phenotypes to clarify the relationship between FUS3/DAC2, STE7 or STE11 and CDC gene products (CDC28, 36, 37 and 39). The results indicate that FUS3/DAC2 may act upstream of CDC28 and provide evidence that the G1 arrest and morphological changes conferred by the cdc37 mutation may require FUS3/DAC2 (MAP kinase), STE7(MEK) and STE11 (MEK kinase)"
Keywords:"Animals CDC28 Protein Kinase, S cerevisiae/genetics/metabolism Calcium-Calmodulin-Dependent Protein Kinases/genetics/*physiology *Cell Cycle Proteins Cell Fusion Cyclins/genetics/*physiology *Drosophila Proteins Enzyme Induction Fungal Proteins/genetics/m;"
Notes:"MedlineFujimura, H A eng Comparative Study England 1994/09/01 J Cell Sci. 1994 Sep; 107 ( Pt 9):2617-22. doi: 10.1242/jcs.107.9.2617"

 
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