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Fungal Genet Biol

Title:		"The pheromone response module, a mitogen-activated protein kinase pathway implicated in the regulation of fungal development, secondary metabolism and pathogenicity"
Author(s):		Frawley D; Bayram O;
Address:		"Biology Department, Callan Building, Maynooth University, Maynooth, Co. Kildare, Ireland. Electronic address: dean.frawley@mu.ie. Biology Department, Callan Building, Maynooth University, Maynooth, Co. Kildare, Ireland. Electronic address: ozgur.bayram@mu.ie"
Journal Title:		Fungal Genet Biol
Year:		2020
Volume:		20200918
Issue:
Page Number:		103469 -
DOI:		10.1016/j.fgb.2020.103469
ISSN/ISBN:		1096-0937 (Electronic) 1087-1845 (Linking)
Abstract:		"Mitogen-activated protein kinase (MAPK) pathways are highly conserved from yeast to human and are required for the regulation of a multitude of biological processes in eukaryotes. A pentameric MAPK pathway known as the Fus3 pheromone module was initially characterised in Saccharomyces cerevisiae and was shown to regulate cell fusion and sexual development. Individual orthologous pheromone module genes have since been found to be highly conserved in fungal genomes and have been shown to regulate a diverse array of cellular responses, such as cell growth, asexual and sexual development, secondary metabolite production and pathogenicity. However, information regarding the assembly and structure of orthologous pheromone modules, as well as the mechanisms of signalling and their biological significance is limited, specifically in filamentous fungal species. Recent studies have provided insight on the utilization of the pheromone module as a central signalling hub for the co-ordinated regulation of fungal development and secondary metabolite production. Various proteins of this pathway are also known to regulate reproduction and virulence in a range of plant pathogenic fungi. In this review, we discuss recent findings that help elucidate the structure of the pheromone module pathway in a myriad of fungal species and its implications in the control of fungal growth, development, secondary metabolism and pathogenicity"
Keywords:		"Fungi/genetics/pathogenicity Genome, Fungal/genetics Humans Mitogen-Activated Protein Kinases/*genetics Pheromones/*genetics Phosphorylation/genetics Saccharomyces cerevisiae/genetics Saccharomyces cerevisiae Proteins/*genetics Secondary Metabolism/*genet;"
Notes:		"MedlineFrawley, Dean Bayram, Ozgur eng Research Support, Non-U.S. Gov't Review 2020/09/21 Fungal Genet Biol. 2020 Nov; 144:103469. doi: 10.1016/j.fgb.2020.103469. Epub 2020 Sep 18"