| Title: | Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation |
| Author(s): | Caponio GR; Celano G; Calabrese FM; Riezzo G; Orlando A; D'Attoma B; Ignazzi A; Vacca M; Porrelli A; Tutino V; De Angelis M; Giannelli G; Russo F; |
| Address: | "National Institute of Gastroenterology 'S. de Bellis' Research Hospital, 70013 Castellana Grotte, Italy. Department of Soil, Plant and Food Science, University of Bari Aldo Moro, 70126 Bari, Italy" |
| ISSN/ISBN: | 2072-6643 (Electronic) 2072-6643 (Linking) |
| Abstract: | "Since irritable bowel syndrome (IBS)-a common gastrointestinal (GI) disorder-still lacks effective therapy, a nutritional approach may represent a practical alternative. Different reports demonstrated that a low-fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) diet (LFD) reduces symptoms in IBS with diarrhea (IBS-D) patients, also inducing beneficial pathophysiological and biochemical modifications. More recently, diets with alternative cereals having a different gluten composition, such as tritordeum, have also been considered (TBD). We investigated the impact of TBD and LFD on the fecal metabolome composition in 38 IBS-D patients randomly allocated to the two diets for 12 weeks. Summarily, at baseline, the profile of fecal volatile organic compounds (VOCs) of IBS-D patients was not significantly different in the two groups. After treatment, significant changes were observed in the two groups regarding the VOCs content since some of them increased in the TBD group (namely, decanoic acid), whereas others (i.e., nonanal and ethanol) increased in the LFD one. Further, at baseline, short-chain fatty acids were positively related to inflammation and showed a significant decreasing trend after both diets compared to baseline values (namely, acetic and propanoic acid). Preliminary results from this pilot study suggest a potential positive intervention of TBD and LFD affecting the fecal metabolome composition in IBS-D patients" |
| Keywords: | "Humans *Monosaccharides *Irritable Bowel Syndrome Disaccharides Pilot Projects Oligosaccharides Diet Metabolome Fermentation Diet, Carbohydrate-Restricted Tritordeum functional gastrointestinal disorders irritable bowel syndrome short-chain fatty acids vo;" |
| Notes: | "MedlineCaponio, Giusy Rita Celano, Giuseppe Calabrese, Francesco Maria Riezzo, Giuseppe Orlando, Antonella D'Attoma, Benedetta Ignazzi, Antonia Vacca, Mirco Porrelli, Annalisa Tutino, Valeria De Angelis, Maria Giannelli, Gianluigi Russo, Francesco eng RC 2020-2021, Prog. N degrees 16 (DDG n. 700/2020)./Italian Ministry of Health/ Switzerland 2022/11/12 Nutrients. 2022 Nov 2; 14(21):4628. doi: 10.3390/nu14214628" |
