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Cell

Title:		The yeast STE12 product is required for expression of two sets of cell-type specific genes
Author(s):		Fields S; Herskowitz I;
Address:
Journal Title:		Cell
Year:		1985
Volume:		42
Issue:		3
Page Number:		923 - 930
DOI:		10.1016/0092-8674(85)90288-0
ISSN/ISBN:		0092-8674 (Print) 0092-8674 (Linking)
Abstract:		"Yeast alpha and a cells transcribe distinct sets of genes involved in mating behavior, alpha-specific genes and a-specific genes, respectively. The alpha 1 product of the alpha mating type locus (MAT alpha) has been the only known activator of either set of genes; it is required for synthesis of RNA from the alpha-specific genes, one of which is the major alpha-factor gene. By screening for mutants that are no longer able to express this gene, we have identified the STE12 gene product as another positive regulator of the alpha-factor gene. alpha ste12 cells are also defective in RNA production from the other known alpha-specific genes. Moreover, a ste12 cells fail to produce wild-type levels of RNA from the a-specific genes. The STE12 gene product is therefore an activator of two sets of genes involved in yeast cell type specialization"
Keywords:		"*Genes *Genes, Fungal *Genes, Mating Type, Fungal Mating Factor Peptides/*genetics Pheromones/*genetics Plasmids Saccharomyces cerevisiae/enzymology/*genetics Species Specificity *Transcription, Genetic beta-Galactosidase/genetics;"
Notes:		"MedlineFields, S Herskowitz, I eng AI-18738/AI/NIAID NIH HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 1985/10/01 Cell. 1985 Oct; 42(3):923-30. doi: 10.1016/0092-8674(85)90288-0"