| Title: | "Trace-level determination of 1,4-dioxane in water by isotopic dilution GC and GC-MS" |
| Author(s): | Draper WM; Dhoot JS; Remoy JW; Perera SK; |
| Address: | "Sanitation and Radiation Laboratory Branch, California Department of Health Services, Berkeley 94704, USA" |
| ISSN/ISBN: | 0003-2654 (Print) 0003-2654 (Linking) |
| Abstract: | "The volatile and polar solvent 1,4-dioxane has recently been reported as a contaminant of ground and surface waters, establishing the need to determine this substance in drinking water. This investigation established that 1,4-dioxane can be determined in water by various techniques including direct aqueous injection (DAI) gas chromatography (GC) and purge and trap GC-mass spectrometry (MS). Purge and trap GC-MS is limited by 1,4-dioxane's poor purge efficiency, resulting in detection limits up to 100 times greater than the efficiently purged volatile organic compounds. To attain the sensitivity required for drinking water monitoring, a method based on continuous liquid-liquid extraction with dichloromethane was developed. Isotope dilution was more accurate and reproducible than quantification with external standards, and the improvement in precision led to a lower method detection limit, 0.2 microgram L-1, using a quadrupole ion trap instrument in the electron ionization mode. Isotope dilution accuracy approached 100% in ppb determinations. Isotopic dilution quantification was also possible using a non-selective GC detector owing to the high efficiency of capillary GC columns that resolve the deuterium-labeled solvent from the natural isotopes" |
| Keywords: | "Chromatography, Gas Dioxanes/*analysis Gas Chromatography-Mass Spectrometry Radioisotope Dilution Technique Sensitivity and Specificity Water Pollutants, Chemical/*analysis;" |
| Notes: | "MedlineDraper, W M Dhoot, J S Remoy, J W Perera, S K eng England 2000/09/26 Analyst. 2000 Aug; 125(8):1403-8. doi: 10.1039/b002345k" |
