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Environ Toxicol

Title:		Toxicogenomic analysis of the pulmonary toxic effects of hexanal in F344 rat
Author(s):		Cho Y; Lim JH; Song MK; Jeong SC; Lee K; Heo Y; Kim TS; Ryu JC;
Address:		"Center for Environment, Health and Welfare Research, Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and Technology (KIST), P.O. Box 131, Cheongryang, Seoul, 130-650, Korea. School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Seoungbuk-Gu, Seoul, 136-701, Korea. Human and Environmental Toxicology, University of Science and Technology, Gajeong-Ro 217, Yuseong-Gu, Daejeon, 305-350, Korea. Inhalation Toxicology Research Center, Korea Institute of Toxicology, 30, Baekhak 1-Gil, Jeongeup-Si, Jeollabuk-Do, 580-185, Korea"
Journal Title:		Environ Toxicol
Year:		2017
Volume:		20160216
Issue:		2
Page Number:		382 - 396
DOI:		10.1002/tox.22242
ISSN/ISBN:		1522-7278 (Electronic) 1520-4081 (Linking)
Abstract:		"Hexanal is a major component of indoor air pollutants and is a kind of aldehydes; it has adverse effects on human health. We performed an in vivo inhalation study and transcriptomic analysis to determine the mode of toxic actions in response to hexanal. Fischer 344 rats of both sexes were exposed by inhalation to hexanal aerosol for 4 h day(-1) , 5 days week(-1) for 4 weeks at 0, 600, 1000, and 1500 ppm. Throughout our microarray-based genome-wide expression analysis, we identified 56 differentially expressed genes in three doses of hexanal; among these genes, 11 genes showed dose-dependent expression patterns (10 downregulated and 1 upregulated, 1.5-fold, p < 0.05). Through a comparative toxicogenomics database (CTD) analysis of 11 genes, we determined that five genes (CCL12, DDIT4, KLF2, CEBPD, and ADH6) are linked to diverse disease categories such as cancer, respiratory tract disease, and immune system disease. These diseases were previously known for being induced by volatile organic compounds (VOCs). Our data demonstrated that the hexanal-induced dose-dependent altered genes could be valuable quantitative biomarkers to predict hexanal exposure and to perform relative risk assessments, including pulmonary toxicity. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 382-396, 2017"
Keywords:		"Air Pollutants, Occupational/*toxicity Air Pollution, Indoor/*adverse effects Aldehydes/*toxicity Animals Databases, Genetic Female Gene Expression Regulation/drug effects Lung/drug effects/metabolism/pathology Lung Diseases/*chemically induced/*genetics/;"
Notes:		"MedlineCho, Yoon Lim, Jung-Hee Song, Mi-Kyung Jeong, Seung-Chan Lee, Kyuhong Heo, Yongju Kim, Tae Sung Ryu, Jae-Chun eng 2016/02/18 Environ Toxicol. 2017 Feb; 32(2):382-396. doi: 10.1002/tox.22242. Epub 2016 Feb 16"