| Title: | Prediction of Inflammatory Bowel Disease Course Based on Fecal Scent |
| Author(s): | Bosch S; Wintjens DSJ; Wicaksono A; Pierik M; Covington JA; de Meij TGJ; de Boer NKH; |
| Address: | "Department of Gastroenterology and Hepatology, AG&M Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands. Department of Gastroenterology and Hepatology, MUMC+, Maastricht University, 6229 HX Maastricht, The Netherlands. School of Engineering, University of Warwick, Coventry CV4 7AL, UK. Department of Pediatric Gastroenterology, AG&M Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands" |
| ISSN/ISBN: | 1424-8220 (Electronic) 1424-8220 (Linking) |
| Abstract: | "The early prediction of changes in disease state allows timely treatment of patients with inflammatory bowel disease (IBD) to be performed, which improves disease outcome. The aim of this pilot study is to explore the potential of fecal volatile organic compound (VOC) profiles to predict disease course. In this prospective cohort, IBD patients were asked to collect two fecal samples and fill in a questionnaire at set intervals. Biochemically, active disease was defined by FCP >/= 250 mg/g and remission was defined by FCP < 100 mg/g. Clinically, active disease was defined by a Harvey Bradshaw Index (HBI) >/= 5 for Crohn's disease or by a Simple Clinical Colitis Activity Index (SCCAI) >/= 3 for ulcerative colitis. Clinical remission was defined by an HBI < 4 or SCCAI |
| Keywords: | "*Colitis, Ulcerative/diagnosis Humans *Inflammatory Bowel Diseases/diagnosis Odorants Pilot Projects Prospective Studies biomarker inflammatory bowel disease volatile organic compounds;" |
| Notes: | "MedlineBosch, Sofie Wintjens, Dion S J Wicaksono, Alfian Pierik, Marieke Covington, James A de Meij, Tim G J de Boer, Nanne K H eng Takeda (Netherlands)/ Switzerland 2022/03/27 Sensors (Basel). 2022 Mar 17; 22(6):2316. doi: 10.3390/s22062316" |
