| Title: | Sniffing the unique 'odor print' of non-small-cell lung cancer with gold nanoparticles |
| Author(s): | Barash O; Peled N; Hirsch FR; Haick H; |
| Address: | "Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa 32000, Israel" |
| ISSN/ISBN: | 1613-6829 (Electronic) 1613-6810 (Print) 1613-6810 (Linking) |
| Abstract: | "A highly sensitive and fast-response array of sensors based on gold nanoparticles, in combination with pattern recognition methods, can distinguish between the odor prints of non-small-cell lung cancer and negative controls with 100% accuracy, with no need for preconcentration techniques. Additionally, preliminary results indicate that the same array of sensors might serve as a better tool for understanding the biochemical source of volatile organic compounds that might occur in cancer cells and appear in the exhaled breath, as compared to traditional spectrometry techniques. The reported results provide a launching pad to initiate a bedside tool that might be able to screen for early stages of lung cancer and allow higher cure rates. In addition, such a tool might be used for the immediate diagnosis of fresh (frozen) tissues of lung cancer in operating rooms, where a dichotomic diagnosis is crucial to guide surgeons" |
| Keywords: | "Carcinoma, Non-Small-Cell Lung/*chemistry/*diagnosis Cell Line, Tumor Diagnosis, Computer-Assisted/*methods Gas Chromatography-Mass Spectrometry/*methods *Gold Humans *Nanoparticles Pattern Recognition, Automated/methods Reproducibility of Results Sensiti;" |
| Notes: | "MedlineBarash, Orna Peled, Nir Hirsch, Fred R Haick, Hossam eng P50 CA058187/CA/NCI NIH HHS/ Evaluation Study Research Support, Non-U.S. Gov't Germany 2009/08/26 Small. 2009 Nov; 5(22):2618-24. doi: 10.1002/smll.200900937" |
