Bedoukian   RussellIPM   RussellIPM   Piezoelectric Micro-Sprayer


Home
Animal Taxa
Plant Taxa
Semiochemicals
Floral Compounds
Semiochemical Detail
Semiochemicals & Taxa
Synthesis
Control
Invasive spp.
References

Abstract

Guide

Alphascents
Pherobio
InsectScience
E-Econex
Counterpart-Semiochemicals
Print
Email to a Friend
Kindly Donate for The Pherobase

« Previous AbstractThe serotonin circuit that coordinates germline proliferation and egg laying with other reproductive functions in Caenorhabditis elegans    Next AbstractPotential of MurA Enzyme and GBAP in Fsr Quorum Sensing System as Antibacterial Drugs Target: In vitro and In silico Study of Antibacterial Compounds from Myrmecodia pendans »

Dev Biol


Title:Serotonergic signaling plays a deeply conserved role in improving oocyte quality
Author(s):Aprison EZ; Dzitoyeva S; Ruvinsky I;
Address:"Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA. Department of Molecular Biosciences, Northwestern University, Evanston, IL, 60208, USA. Electronic address: ilya.ruvinsky@northwestern.edu"
Journal Title:Dev Biol
Year:2023
Volume:20230428
Issue:
Page Number:24 - 30
DOI: 10.1016/j.ydbio.2023.04.008
ISSN/ISBN:1095-564X (Electronic) 0012-1606 (Print) 0012-1606 (Linking)
Abstract:"Declining germline quality is a major cause of reproductive senescence. Potential remedies could be found by studying regulatory pathways that promote germline quality. Several lines of evidence, including a C. elegans male pheromone ascr#10 that counteracts the effects of germline aging in hermaphrodites, suggest that the nervous system plays an important role in regulating germline quality. Inspired by the fact that serotonin mediates ascr#10 signaling, here we show that serotonin reuptake inhibitors recapitulate the effects of ascr#10 on the germline and promote healthy oocyte aging in C. elegans. Surprisingly, we found that pharmacological increase of serotonin signaling stimulates several developmental processes in D. melanogaster, including improved oocyte quality, although underlying mechanisms appear to be different between worms and flies. Our results reveal a plausibly conserved role for serotonin in maintaining germline quality and identify a class of therapeutic interventions using available compounds that could efficiently forestall reproductive aging"
Keywords:Animals Male *Caenorhabditis elegans/genetics/metabolism Serotonin/metabolism/pharmacology Drosophila melanogaster/metabolism Oocytes/metabolism Germ Cells/metabolism *Caenorhabditis elegans Proteins/genetics/metabolism C.elegans D.melanogaster Germline;
Notes:"MedlineAprison, Erin Z Dzitoyeva, Svetlana Ruvinsky, Ilya eng R01 GM126125/GM/NIGMS NIH HHS/ P40 OD010440/OD/NIH HHS/ U41 HG002223/HG/NHGRI NIH HHS/ Research Support, N.I.H., Extramural 2023/05/01 Dev Biol. 2023 Jul; 499:24-30. doi: 10.1016/j.ydbio.2023.04.008. Epub 2023 Apr 28"

 
Back to top
 
Citation: El-Sayed AM 2024. The Pherobase: Database of Pheromones and Semiochemicals. <http://www.pherobase.com>.
© 2003-2024 The Pherobase - Extensive Database of Pheromones and Semiochemicals. Ashraf M. El-Sayed.
Page created on 23-11-2024