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J Hazard Mater


Title:Interaction of inhalable volatile organic compounds and pulmonary surfactant: Potential hazards of VOCs exposure to lung
Author(s):Zhao Q; Li Y; Chai X; Xu L; Zhang L; Ning P; Huang J; Tian S;
Address:"Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. Electronic address: yjli@kmust.edu.cn. Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China. Electronic address: tiansenlin@outlook.com"
Journal Title:J Hazard Mater
Year:2019
Volume:20190131
Issue:
Page Number:512 - 520
DOI: 10.1016/j.jhazmat.2019.01.104
ISSN/ISBN:1873-3336 (Electronic) 0304-3894 (Linking)
Abstract:"Exposure of volatile organic compounds (VOCs) towards lung leads to pulmonary dysfunctions and various lung diseases. However, the interaction of VOCs with pulmonary surfactant (PS) that directly comes into contact with inhaled VOCs is unknown. Here, simulated PS extracted from porcine lungs (EPS) was used to study the interaction with BTEX (i.e., benzene, toluene, ethylbenzene, and p-xylene) as representatives of VOCs. Surface pressure-area (pi-A) isotherms showed that in the presence of individual BTEX, EPS monolayer's phase conversion from gas to liquid expanded phase was dramatically influenced and its collapse pressure decreased greatly compared to those of EPS alone, which was attributed to the alteration of EPS monolayer's microstructure characterized by atomic force microscopy and Brewster angle microscopy. Solubilization experiments manifested that EPS and its major components (dipalmitoyl phosphatidylcholine, DPPC; bovine serum albumin, BSA) exhibited obvious solubilization effects on individual BTEX. The solubilization capacity followed an order: EPS > DPPC > BSA, which was positively correlated with hydrophobicity of individual BTEX. Synergistic solubilization test unveiled that the mixed phospholipid components were largely responsible for the solubilization capacity of EPS. These findings indicate that VOCs exposure may induce potential pulmonary health risk due to the alteration of gas-liquid interfacial properties of PS"
Keywords:"1, 2-Dipalmitoylphosphatidylcholine/chemistry Animals Environmental Exposure Environmental Monitoring Lung/pathology/ultrastructure Lung Diseases/*chemically induced/pathology Microscopy, Atomic Force Phospholipids/chemistry Pulmonary Surfactants/*chemistr;"
Notes:"MedlineZhao, Qun Li, Yingjie Chai, Xiaolong Xu, Linzhen Zhang, Linfeng Ning, Ping Huang, Jianhong Tian, Senlin eng Research Support, Non-U.S. Gov't Netherlands 2019/02/27 J Hazard Mater. 2019 May 5; 369:512-520. doi: 10.1016/j.jhazmat.2019.01.104. Epub 2019 Jan 31"

 
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