| Title: | Natural ligands of hamster aphrodisin |
| Author(s): | Briand L; Blon F; Trotier D; Pernollet JC; |
| Address: | "Biochimie de l'Olfaction et de la Gustation, Neurobiologie de l'Olfaction et de la Prise Alimentaire, batiment 526, Domaine de Vilvert, F-78352, Jouy-en-Josas Cedex, France" |
| ISSN/ISBN: | 0379-864X (Print) 0379-864X (Linking) |
| Abstract: | "The chemical nature of vertebrate pheromones remains largely to be deciphered. Hamster aphrodisin is a rare instance of mammal proteinaceous sexual pheromone. This protein, found in vaginal secretions, facilitates the mounting behaviour of males via activation of a specialized sensory structure named the vomeronasal organ, which activates the accessory olfactory bulb. Since it might carry small pheromonal ligands due to its lipocalin structure, we analysed organic extracts from natural aphrodisin. We identified five predominant compounds specifically bound onto natural aphrodisin as 1-hexadecanol (44.7%), 1-octadecanol (19.5%), Z-9-octadecen-1-ol (18.2%), E-9-octadecen-1-ol (15.4%) and hexadecanoic acid (2.2%). Interestingly, these compounds are also described as part of insect pheromone blends, disclosing the continuing story of amazing coincidences of chemical communication shared by mammals and insects" |
| Keywords: | "Animals Chromatography, Gas Cricetinae Electrophoresis, Polyacrylamide Gel Female Ligands Male Mammals Mass Spectrometry Olfactory Pathways/*physiology Pheromones/chemistry/genetics/*metabolism Proteins/chemistry/*metabolism Sex Attractants/chemistry/gene;" |
| Notes: | "MedlineBriand, Loic Blon, Florence Trotier, Didier Pernollet, Jean-Claude eng England 2004/06/18 Chem Senses. 2004 Jun; 29(5):425-30. doi: 10.1093/chemse/bjh044" |
