| Title: | Inhaled Pollutants: The Molecular Scene behind Respiratory and Systemic Diseases Associated with Ultrafine Particulate Matter |
| Author(s): | Traboulsi H; Guerrina N; Iu M; Maysinger D; Ariya P; Baglole CJ; |
| Address: | "Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. Hussein.Traboulsi@mail.mcgill.ca. Department of Pathology, McGill University, Montreal, QC H4A 3J1, Canada. Necola.guerrina@mail.mcgill.ca. Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. matthew.iu@mail.mcgill.ca. Department of Pharmacology & Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada. Dusica.maysinger@mcgill.ca. Department of Chemistry, McGill University, Montreal, QC H3A 2K6, Canada. parisa.ariya@mcgill.ca. Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. Carolyn.baglole@mcgill.ca. Department of Pathology, McGill University, Montreal, QC H4A 3J1, Canada. Carolyn.baglole@mcgill.ca. Department of Pharmacology & Therapeutics, McGill University, Montreal, QC H3G 1Y6, Canada. Carolyn.baglole@mcgill.ca" |
| ISSN/ISBN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
| Abstract: | "Air pollution of anthropogenic origin is largely from the combustion of biomass (e.g., wood), fossil fuels (e.g., cars and trucks), incinerators, landfills, agricultural activities and tobacco smoke. Air pollution is a complex mixture that varies in space and time, and contains hundreds of compounds including volatile organic compounds (e.g., benzene), metals, sulphur and nitrogen oxides, ozone and particulate matter (PM). PM(0.1) (ultrafine particles (UFP)), those particles with a diameter less than 100 nm (includes nanoparticles (NP)) are considered especially dangerous to human health and may contribute significantly to the development of numerous respiratory and cardiovascular diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis. Some of the pathogenic mechanisms through which PM(0.1) may contribute to chronic disease is their ability to induce inflammation, oxidative stress and cell death by molecular mechanisms that include transcription factors such as nuclear factor kappaB (NF-kappaB) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Epigenetic mechanisms including non-coding RNA (ncRNA) may also contribute towards the development of chronic disease associated with exposure to PM(0.1). This paper highlights emerging molecular concepts associated with inhalational exposure to PM(0.1) and their ability to contribute to chronic respiratory and systemic disease" |
| Keywords: | "Air Pollutants/*adverse effects Air Pollution/*adverse effects Animals Antioxidants/metabolism Biomarkers Cell Death *Disease Susceptibility Epigenesis, Genetic Genetic Predisposition to Disease Humans Inflammation/etiology/metabolism Oxidative Stress Par;" |
| Notes: | "MedlineTraboulsi, Hussein Guerrina, Necola Iu, Matthew Maysinger, Dusica Ariya, Parisa Baglole, Carolyn J eng Review Switzerland 2017/01/27 Int J Mol Sci. 2017 Jan 24; 18(2):243. doi: 10.3390/ijms18020243" |
