| Title: | Are polyamines involved in olfaction? An EAG and biochemical study in Periplaneta americana antennae |
| Author(s): | Tirard A; Renucci M; Provost E; Khlat J; Clement JL; |
| Address: | "CNRS, Laboratoire de Neurobiologie, FRE 2092, 31 chemin Joseph-Aiguier, F-13402 Marseille cedex 20, France. tirard@lnb.cnrs-mrs.fr" |
| ISSN/ISBN: | 0379-864X (Print) 0379-864X (Linking) |
| Abstract: | "Polyamines have been implicated in modulation of numerous cell functions. The purpose of this study was to assess the role of polyamines in intracellular regulation of insect antenna. Analysis of study data showed two main findings. First, in vivo treatment with the polyamine synthesis inhibitor alpha-difluoromethyl-ornithine enhanced the sensitivity of male Periplaneta americana antenna to female pheromonal blend. Secondly, polyamine modulated phosphorylation of several antennary proteins including two found exclusively in antenna (30 and 48 kDa). In both of these exclusive antennary proteins, phosphorylation changed after stimulation with the pheromonal blend. These results suggest that polyamines play a regulatory role in detection of female pheromonal blend and that modulation of protein phosphorylation is one of the mechanisms involved in this regulation" |
| Keywords: | "Animals Autoradiography Biogenic Polyamines/antagonists & inhibitors/biosynthesis/*physiology Casein Kinase II Eflornithine/pharmacology Electrophoresis, Polyacrylamide Gel Electrophysiology/methods Female Insect Proteins/*drug effects/*metabolism Male Pe;" |
| Notes: | "MedlineTirard, Alain Renucci, Marielle Provost, Erick Khlat, Jacqueline Clement, Jean-Luc eng Comparative Study England 2002/06/08 Chem Senses. 2002 Jun; 27(5):417-23. doi: 10.1093/chemse/27.5.417" |
