« Previous Abstract"Function and expression of the Drosophila gr genes in the perception of sweet, bitter and pheromone compounds"    Next Abstract"Induction of silicon defences in wheat landraces is local, not systemic, and driven by mobilization of soluble silicon to damaged leaves" »

J Comp Neurol

Title:		Atypical expression of Drosophila gustatory receptor genes in sensory and central neurons
Author(s):		Thorne N; Amrein H;
Address:		"Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA"
Journal Title:		J Comp Neurol
Year:		2008
Volume:		506
Issue:		4
Page Number:		548 - 568
DOI:		10.1002/cne.21547
ISSN/ISBN:		0021-9967 (Print) 0021-9967 (Linking)
Abstract:		"Members of the Drosophila gustatory receptor (Gr) gene family are generally expressed in chemosensory neurons and are known to mediate the perception of sugars, bitter substrates, CO(2), and pheromones. The Gr gene family consists of 68 members, many of which are organized in gene clusters of up to six genes, yet only expression of about 15 Gr genes has been characterized in detail prior to this study. Here we describe the first comprehensive expression analysis of six highly conserved Gr genes, Gr28a and Gr28b.a to Gr28b.e. Four of these Gr genes are not only expressed in the characteristic pattern associated with previously analyzed Gr genes-chemosensory neurons of the gustatory and olfactory system-but several other types of sensory neurons and neurons in the brain. Specifically, we show that several of the Gr28 genes are expressed in abdominal multidendritic neurons, putative hygroreceptive neurons of the arista, neurons associated with the Johnston's organ, peripheral proprioceptive neurons in the legs, neurons in the larval and adult brain, and oenocytes. Thus, our findings suggest that some Gr genes are utilized in nongustatory roles in the nervous system and tissues involved in proprioception, hygroreception, and other sensory modalities. It is also possible that the Gr28 genes have chemosensory roles in the detection of internal ligands"
Keywords:		"Alternative Splicing/genetics Animals Animals, Genetically Modified Body Patterning/genetics Brain/cytology/embryology/metabolism Central Nervous System/cytology/embryology/metabolism Chemoreceptor Cells/cytology/*metabolism Drosophila Proteins/*genetics;"
Notes:		"MedlineThorne, Natasha Amrein, Hubert eng R01 DC005606/DC/NIDCD NIH HHS/ R01 DC009014/DC/NIDCD NIH HHS/ R01 GMDC05606-01/PHS HHS/ Research Support, N.I.H., Extramural 2007/12/11 J Comp Neurol. 2008 Feb 1; 506(4):548-68. doi: 10.1002/cne.21547"