« Previous AbstractDevelopment of Solid Ceramic Dosimeters for the Time-Integrative Passive Sampling of Volatile Organic Compounds in Waters    Next AbstractImportance of enhanced mass resolution in removing interferences when measuring volatile organic compounds in human blood by using purge-and-trap gas chromatography/mass spectrometry »

Leukemia

Title:		Hematopoietic stem cell mobilization: updated conceptual renditions
Author(s):		Bonig H; Papayannopoulou T;
Address:		"Department of Medicine/Division of Hematology, University of Washington, Seattle, WA 98198-7720, USA"
Journal Title:		Leukemia
Year:		2013
Volume:		20120906
Issue:		1
Page Number:		24 - 31
DOI:		10.1038/leu.2012.254
ISSN/ISBN:		1476-5551 (Electronic) 0887-6924 (Print) 0887-6924 (Linking)
Abstract:		"Despite its specific clinical relevance, the field of hematopoietic stem cell mobilization has received broad attention, owing mainly to the belief that pharmacologic stem cell mobilization might provide clues as to how stem cells are retained in their natural environment, the bone marrow 'niche'. Inherent to this knowledge is also the desire to optimally engineer stem cells to interact with their target niche (such as after transplantation), or to lure malignant stem cells out of their protective niches (in order to kill them), and in general to decipher the niche's structural components and its organization. Whereas, with the exception of the recent addition of CXCR4 antagonists to the armamentarium for mobilization of patients refractory to granulocyte colony-stimulating factor alone, clinical stem cell mobilization has not changed significantly over the last decade or so, much effort has been made trying to explain the complex mechanism(s) by which hematopoietic stem and progenitor cells leave the marrow. This brief review will report some of the more recent advances about mobilization, with an attempt to reconcile some of the seemingly inconsistent data in mobilization and to interject some commonalities among different mobilization regimes"
Keywords:		Animals *Bone Marrow *Hematopoietic Stem Cell Mobilization Humans *Stem Cell Niche;
Notes:		"MedlineBonig, H Papayannopoulou, T eng R01 DK094702/DK/NIDDK NIH HHS/ R01 HL058734/HL/NHLBI NIH HHS/ HL58734/HL/NHLBI NIH HHS/ DK094702/DK/NIDDK NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review England 2012/09/07 Leukemia. 2013 Jan; 27(1):24-31. doi: 10.1038/leu.2012.254. Epub 2012 Sep 6"