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Analyst

Title:		Determination of physiological levels of volatile organic compounds in blood using static headspace capillary gas chromatography with serial triple detection
Author(s):		Schroers HJ; Jermann E; Begerow J; Hajimiragha H; Chiarotti-Omar AM; Dunemann L;
Address:		"Medizinisches Institut fur Umwelthygiene, Department of Analytical Chemistry, Dusseldorf, Germany"
Journal Title:		Analyst
Year:		1998
Volume:		123
Issue:		4
Page Number:		715 - 720
DOI:		10.1039/a706226e
ISSN/ISBN:		0003-2654 (Print) 0003-2654 (Linking)
Abstract:		"A static capillary gas chromatographic method using three different detectors [photoionization detector (PID), electron capture detector (ECD) and flame ionization detector (FID)] switched in series is presented for the determination of volatile organic compounds (VOCs) in sub microgram l-1 levels. The method was applied for the analysis of selected environmentally and occupationally relevant non-halogenated and chlorinated aromatic hydrocarbons (e.g., benzene, toluene, xylenes, dichlorobenzenes) as well as chlorinated aliphatic hydrocarbons (e.g., trichloroethene, tetrachloroethene) in blood samples. Detailed investigations, in respect to the figures of merit were carried out. For most of the selected VOCs detection limits (calculated as the three-fold standard deviation of low level calibration standards) in the range from 26 (benzene) to 67 ng l-1 (m/p-xylene) were achieved which are comparable with those reported for dynamic headspace techniques in combination with mass spectrometric detection. For the individual VOCs the within-series precision varied from 4 to 19% and the day-to-day precision from 11 to 28%. Regarding PID as well as FID the calibration graphs for all substances were linear up to at least 10 micrograms l-1 while the ECD response was linear up to concentrations of about 0.6 microgram l-1 for the halogenated compounds. Our method is applicable for the quantitative determination of VOCs in blood in the occupationally as well as in the physiologically relevant (normal) concentration range"
Keywords:		"Air Pollutants/*blood Chromatography, Gas/instrumentation/methods *Environmental Exposure Humans Hydrocarbons/*blood;"
Notes:		"MedlineSchroers, H J Jermann, E Begerow, J Hajimiragha, H Chiarotti-Omar, A M Dunemann, L eng England 1998/07/31 Analyst. 1998 Apr; 123(4):715-20. doi: 10.1039/a706226e"