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Exp Parasitol

Title:		Anti-Acanthamoeba activity of Tunisian Thymus capitatus essential oil and organic extracts
Author(s):		Saoudi S; Sifaoui I; Chammem N; Reyes-Batlle M; Lopez-Arencibia A; Pacheco-Fernandez I; Pino V; Hamdi M; Jimenez IA; Bazzocchi IL; Pinero JE; Lorenzo-Morales J;
Address:		"Laboratoire d'Ecologie et de Technologie Microbiennes, Institut National des Sciences Appliquees et de Technologie, INSAT, University of Carthage, 2 Boulevard de la Terre, BP 676, 1080 Tunis, Tunisia. Electronic address: salma.saoudi@yahoo.fr. Laboratoire Materiaux-Molecules et Applications, IPEST, University of Carthage, B.P. 51, 2070 La Marsa, Tunisia; University Institute of Tropical Diseases and Public Health, University of La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271 La Laguna, Tenerife, Canary Islands, Spain. Laboratoire d'Ecologie et de Technologie Microbiennes, Institut National des Sciences Appliquees et de Technologie, INSAT, University of Carthage, 2 Boulevard de la Terre, BP 676, 1080 Tunis, Tunisia. University Institute of Tropical Diseases and Public Health, University of La Laguna, Avda Francisco Sanchez s/n, Campus de Anchieta, 38271 La Laguna, Tenerife, Canary Islands, Spain. Departamento de Quimica (Unidad Departamental de Quimica Analitica), Universidad de La Laguna (ULL), La Laguna, Tenerife, Spain. Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Tenerife, Canary Islands, Spain"
Journal Title:		Exp Parasitol
Year:		2017
Volume:		20170912
Issue:
Page Number:		231 - 235
DOI:		10.1016/j.exppara.2017.09.014
ISSN/ISBN:		1090-2449 (Electronic) 0014-4894 (Linking)
Abstract:		"Acanthamoeba species are free-living amoebae widely distributed in the environment and which cause serious human infections. The treatment of Acanthamoeba infections is always very difficult and not constantly effective. More efficient drugs against Acanthamoeba must be developed and medicinal plants can be useful in this case. Our research focused on the examination of the anti-Acanthamoeba activity of the essential oil and the ethanolic-aqueous extract from Thymus capitatus L. The essential oil showed best activity with an IC(50) of 2.73 mug/ml. The conducted Bio-guided fractionation of thyme extract result to the identification of two active compounds against the trophozoite stage of Acanthamoeba: thymol and 2,3-dihydroxy-p-cymene. The results have clearly shown that the investigated products may be successfully used against Acanthamoeba infections. These molecules that are found in plants may be an alternative for the development of new drugs"
Keywords:		"Acanthamoeba/*drug effects Biological Assay Chemical Fractionation Gas Chromatography-Mass Spectrometry Inhibitory Concentration 50 Oils, Volatile/*pharmacology Plant Extracts/*pharmacology Thymus Plant/*chemistry 2, 3-Dihydroxy-p-cymene Acanthamoeba Anti-;"
Notes:		"MedlineSaoudi, Salma Sifaoui, Ines Chammem, Nadia Reyes-Batlle, Maria Lopez-Arencibia, Atteneri Pacheco-Fernandez, Idaira Pino, Veronica Hamdi, Moktar Jimenez, Ignacio A Bazzocchi, Isabel L Pinero, Jose E Lorenzo-Morales, Jacob eng 2017/09/17 Exp Parasitol. 2017 Dec; 183:231-235. doi: 10.1016/j.exppara.2017.09.014. Epub 2017 Sep 12"