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Arch Microbiol

Title:		Effect of anticalmodulin drugs on the action of yeast alpha factor pheromone
Author(s):		Ruiz T; Rodriguez L;
Address:
Journal Title:		Arch Microbiol
Year:		1986
Volume:		145
Issue:		1
Page Number:		104 - 106
DOI:		10.1007/BF00413035
ISSN/ISBN:		0302-8933 (Print) 0302-8933 (Linking)
Abstract:		"Saccharomyces cerevisiae alpha factor pheromone arrest growth of cells of the a mating type (MAT a) at the G1 phase of the cell cycle. When treatment of MAT a cells with alpha factor was carried out in the presence of anticalmodulin drugs, trifluoperazine or chlorpromazine, the extent of cell growth arrest induced by alpha factor was reduced or even became undetectable. These results lend support to the hypothesis that calmodulin plays a role as mediator in the action of alpha factor on MAT a cells"
Keywords:		Calmodulin/*antagonists & inhibitors Chlorpromazine/*pharmacology Kinetics Mating Factor Peptides/*physiology Pheromones/*physiology Saccharomyces cerevisiae/drug effects/*physiology Time Factors Trifluoperazine/*pharmacology;
Notes:		"MedlineRuiz, T Rodriguez, L eng Germany 1986/06/01 Arch Microbiol. 1986 Jun; 145(1):104-6. doi: 10.1007/BF00413035"