| Title: | Increased pentane and carbon disulfide in the breath of patients with schizophrenia |
| Author(s): | Phillips M; Sabas M; Greenberg J; |
| Address: | "Department of Medicine, St Vincent's Medical Center of Richmond, Staten Island, New York 10310-1699" |
| ISSN/ISBN: | 0021-9746 (Print) 1472-4146 (Electronic) 0021-9746 (Linking) |
| Abstract: | "AIMS: To determine the concentrations of pentane (a marker of lipid peroxidation) and other volatile organic compounds in the breath of patients with schizophrenia. METHODS: Volatile organic compounds were assayed by gas chromatography/mass spectroscopy (GC/MS) in 88 subjects--25 with acute schizophrenic psychosis, 26 with psychiatric disorders other than schizophrenia, and 37 normal volunteers. RESULTS: The mean alveolar gradients of pentane and carbon disulfide (CS2) were significantly higher in the patients with schizophrenia than in the control groups. CONCLUSIONS: Schizophrenia may be accompanied by accelerated lipid peroxidation in cell membranes, as well as increased manufacture of CS2, a known neurotoxin" |
| Keywords: | Adult Bipolar Disorder/metabolism Breath Tests Carbon Disulfide/*analysis Cell Membrane/metabolism Depressive Disorder/metabolism Female Gas Chromatography-Mass Spectrometry Humans Male Pentanes/*analysis Pulmonary Alveoli/chemistry Schizophrenia/*metabol; |
| Notes: | "MedlinePhillips, M Sabas, M Greenberg, J eng England 1993/09/01 J Clin Pathol. 1993 Sep; 46(9):861-4. doi: 10.1136/jcp.46.9.861" |
